Surveillance of pneumococcal colonization and invasive pneumococcal disease reveals shift in prevalent carriage serotypes in Massachusetts’ children to relatively low invasiveness

Abstract Background Following the introduction of pneumococcal conjugate vaccines (PCV), overall nasopharyngeal colonization rates have not changed significantly, however a dramatic and sustained decline in invasive pneumococcal disease (IPD) in children was observed in every setting where the PCVs...

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Bibliographic Details
Published in:Vaccine 2017-07, Vol.35 (32), p.4002-4009
Main Authors: Yildirim, I, Little, B.A, Finkelstein, J, Lee, G, Hanage, W.P, Shea, K, Pelton, S.I
Format: Article
Language:English
Subjects:
Adolescent
Age
Allergy and Immunology
Bacteremia - epidemiology
Bacteremia - microbiology
Carriage
Carrier State - epidemiology
Carrier State - microbiology
Child
Child, Preschool
Children
Colonization
Computation
Disease
Epidemiological Monitoring
Epidemiology
Female
Health surveillance
Humans
Incidence
Infant
Infant, Newborn
Invasive disease potential
Invasiveness
Laboratories
Male
Massachusetts - epidemiology
Meningitis, Bacterial - epidemiology
Meningitis, Bacterial - microbiology
Nasopharynx
Pediatrics
Pneumococcal Infections - epidemiology
Pneumococcal Infections - microbiology
Pneumonia
Population
Primary care
Public health
Serogroup
Serotype replacement
Serotypes
Streptococcus infections
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - isolation & purification
Studies
Surveillance
Vaccines
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Summary:Abstract Background Following the introduction of pneumococcal conjugate vaccines (PCV), overall nasopharyngeal colonization rates have not changed significantly, however a dramatic and sustained decline in invasive pneumococcal disease (IPD) in children was observed in every setting where the PCVs were implemented. We aimed to describe the differences in invasive disease potential of serotypes that are common colonizers in pre- and post-vaccine eras in order to provide further insight in our understanding of dynamic epidemiology of pneumococcal diseases. Methods Using data from surveillance of nasopharyngeal carriage and enhanced surveillance for IPD, a serotype specific “invasive capacity (IC)” was computed by dividing the incidence of IPD due to serotype x by the carriage prevalence of that same serotype in children
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2017.05.077