Can Stem Cells Ameliorate the Pancreatic Damage Induced by Streptozotocin in Rats?

Highlights • Diabetes mellitus represents a global health problem. • There is a great deal of interest in stem cell therapy for failing tissue and organs repair. • Mesenchymal stem cells have been isolated from the bone marrow of white male albino rats, then differentiated into insulin-producing cel...

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Bibliographic Details
Published in:Canadian journal of diabetes 2018-02, Vol.42 (1), p.61-70
Main Authors: El Barky, Amira Ragab, PhD, Ezz, Amany Abdel hamid, MSc, Alm-Eldeen, Abeer Abd-Elhameed, PhD, Hussein, Samy Ali, PhD, Hafez, yehia Ahmed, PhD, Mohamed, Tarek Mostafa, PhD
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Cell- and Tissue-Based Therapy
cellules souches mésenchymateuses
diabetes
Diabetes Mellitus, Experimental - therapy
diabète
differentiation
différenciation
Endocrinology & Metabolism
Insulin-Secreting Cells - cytology
Insulin-Secreting Cells - transplantation
Male
Mesenchymal Stem Cell Transplantation
mesenchymal stem cells
Mesenchymal Stromal Cells - cytology
Other
Pancreas - physiopathology
Rats
Regeneration
stem cell therapy
thérapie par les cellules souches
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Summary:Highlights • Diabetes mellitus represents a global health problem. • There is a great deal of interest in stem cell therapy for failing tissue and organs repair. • Mesenchymal stem cells have been isolated from the bone marrow of white male albino rats, then differentiated into insulin-producing cells by using cocktail of growth factor. • Both mesenchymal stem cell and insulin-producing cell therapy have been shown to normalize aberrant biochemical parameters in rats with streptozotocin-induced diabetes.
ISSN:1499-2671
2352-3840
DOI:10.1016/j.jcjd.2017.04.002