Paternal bisphenol a diet changes prefrontal cortex proteome and provokes behavioral dysfunction in male offspring

• Published in: Chemosphere (Oxford) 2017-10, Vol.184, p.720-729
• Main Authors: Luo, Guangying, Wei, Ruifen, Wang, Shaolin, Wang, Jundong
• Format: Article
• Language: English
• Subjects: Animals; Anxiety - chemically induced; Anxiety-like behavior; Behavior - drug effects; Benzhydryl Compounds - metabolism; Benzhydryl Compounds - toxicity; Diet - statistics & numerical data; Environmental Pollutants - toxicity; Female; Immunoglobulin protein; Male; Myelin basic protein; Paternal BPA diet; Phenols - metabolism; Phenols - toxicity; Prefrontal Cortex - metabolism; Pregnancy; Prenatal Exposure Delayed Effects - metabolism; Proteome - metabolism; Social Behavior
• ISSN: 0045-6535; 1879-1298
• DOI: 10.1016/j.chemosphere.2017.06.050

Relatively little attention has been given paternal effects on next generation. Given that Bisphenol A (BPA), a ubiquitous compound in maternal diet, may disrupt brain development and behavior, we hypothesized that paternal BPA diet (PBD) could affect offspring development. Prefrontal cortex (PFC), a vital brain region, is involved in emotion and social behavior. To test whether PBD could alter developing PFC, we carried out a proteomics approach for PFC in male juvenile offspring that responded to PBD (50 mg BPA/kg diet). We found that PBD altered the expressions of binding immunoglobulin protein (BIP), CCAAT/-enhancer-binding protein homologous protein (CHOP) and B-cell lymphoma-2 (BCL-2), which could reflect endoplasmic reticulum (ER) stress. In addition, downregulation of myelinogenesis genes and myelin basic protein (MBP) could provoke myelin deficiency. Furthermore, PBD significantly increased anxiety-like behavior and impaired social behavior in male offspring. Taken together, these results revealed the alterations of ER stress and myelin destruction related molecules induced by PBD might be a potential mechanism for the behavior deficits in their male offspring. These findings remind us of the importance of paternal effects in the further environmental exposure research. •We examined effects of paternal BPA diet on prefrontal cortex proteome of male offspring.•Prefrontal cortical ER stress and myelin deficiency related molecules were changed.•We observed influences of paternal BPA diet on behaviors of male offspring.•Paternal BPA exposure alters social and anxiety-like behavior in male mice.