Bimagrumab improves body composition and insulin sensitivity in insulin‐resistant individuals

• Published in: Diabetes, obesity & metabolism obesity & metabolism, 2018-01, Vol.20 (1), p.94-102
• Main Authors: Garito, Tania, Roubenoff, Ronenn, Hompesch, Marcus, Morrow, Linda, Gomez, Katherine, Rooks, Daniel, Meyers, Charles, Buchsbaum, Monte S., Neelakantham, Srikanth, Swan, Therese, Filosa, Lee Anne, Laurent, Didier, Petricoul, Olivier, Zakaria, Marjorie
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon; activin receptor II; Adipose Tissue, Brown - diagnostic imaging; Adipose Tissue, Brown - drug effects; Adipose Tissue, Brown - metabolism; Adiposity - drug effects; Anti-Obesity Agents - administration & dosage; Anti-Obesity Agents - adverse effects; Anti-Obesity Agents - pharmacokinetics; Anti-Obesity Agents - therapeutic use; Antibodies, Blocking - administration & dosage; Antibodies, Blocking - adverse effects; Antibodies, Blocking - therapeutic use; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - adverse effects; Antibodies, Monoclonal - pharmacokinetics; Antibodies, Monoclonal - therapeutic use; bimagrumab; Body composition; Body fat; Body Mass Index; Body weight; Double-Blind Method; Dual energy X-ray absorptiometry; Female; Follow-Up Studies; Glucose; Glucose Clamp Technique; Glucose Intolerance - blood; Glucose Intolerance - complications; Glucose Intolerance - drug therapy; Glucose Intolerance - metabolism; Glucose tolerance; Glucose Tolerance Test; Glycated Hemoglobin A - analysis; HbA1c; Hemoglobin; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - adverse effects; Hypoglycemic Agents - pharmacokinetics; Hypoglycemic Agents - therapeutic use; Infusions, Intravenous; Insulin; Insulin Resistance; Intravenous administration; Male; Obesity; Obesity - complications; Obesity - diagnostic imaging; Obesity - drug therapy; Obesity - metabolism; Pilot Projects; Positron emission tomography; Positron Emission Tomography Computed Tomography; Thermogenesis - drug effects
• ISSN: 1462-8902; 1463-1326
• DOI: 10.1111/dom.13042

Aim To test the hypothesis that an improving body composition in insulin‐resistant individuals could enhance insulin sensitivity. Methods A total of 16 people with a mean body mass index of 29.3 kg/m2 and insulin resistance, received a single dose of bimagrumab or placebo and were assessed at week 10 for insulin sensitivity, using a hyperinsulinaemic‐euglycaemic clamp and an intravenous glucose tolerance test (IVGTT), and for body composition using dual energy X‐ray absorptiometry and positron‐emission tomography. Results Bimagrumab increased lean mass by 2.7% (P