CT at onset of Chronic Lung Allograft Dysfunction in Lung Transplant Patients Predicts Development of the Restrictive Phenotype and Survival

Highlights • CT in CLAD-patients with and without development of restrictive phenotype differs significantly. • At CLAD onset inflammatory changes indicate future development of restrictive phenotype. • A high CT score for inflammation at CLAD onset is combined with significant lower survival. • CT...

Full description

Saved in:
Bibliographic Details
Published in:European journal of radiology 2017-09, Vol.94, p.78-84
Main Authors: Dettmer, Sabine, Shin, Hoen-oh, Vogel-Claussen, Jens, Westphal, Max, Haverich, Axel, Warnecke, Gregor, Welte, Tobias, Wacker, Frank, Gottlieb, Jens, Suhling, Hendrik
Format: Article
Language:English
Subjects:
Adult
Chronic lung allograft dysfunction
Computed tomography
Disease Progression
Female
Follow-Up Studies
Humans
Interstitial lung disease
Lung Diseases - diagnostic imaging
Lung Diseases - mortality
Lung Diseases - physiopathology
Lung transplantation
Lung Transplantation - adverse effects
Male
Middle Aged
Phenotype
Predictive Value of Tests
Primary Graft Dysfunction - diagnostic imaging
Primary Graft Dysfunction - mortality
Primary Graft Dysfunction - physiopathology
Prognosis
Radiology
Restrictive allograft syndrome
Retrospective Studies
Survival Analysis
Tomography, X-Ray Computed - methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • CT in CLAD-patients with and without development of restrictive phenotype differs significantly. • At CLAD onset inflammatory changes indicate future development of restrictive phenotype. • A high CT score for inflammation at CLAD onset is combined with significant lower survival. • CT indicates the development of restrictive CLAD-phenotype before becoming clinically apparent. • Inflammatory pattern in CT at CLAD onset correlates with a lower survival.
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2017.06.008