Adolescent meningococcal serogroup A, W and Y immune responses following immunization with quadrivalent meningococcal A, C, W and Y conjugate vaccine: Optimal age for vaccination

Highlights • MenACWY-TT vaccine induces robust primary responses against meningococcal serogroups A, W and Y. • 94% of the participants maintain rSBA titers ≥128 against all three serogroups up to one year. • Compared with 12 and 15 years the 10-year-olds show the lowest SBA titers against MenW afte...

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Bibliographic Details
Published in:Vaccine 2017-08, Vol.35 (36), p.4753-4760
Main Authors: van Ravenhorst, Mariëtte B, van der Klis, Fiona R.M, van Rooijen, Debbie M, Sanders, Elisabeth A.M, Berbers, Guy A.M
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Age
Allergy and Immunology
Antibody
Conjugate vaccine
Disease
Fluorescence
Immune response
Immunization
Immunoassay
Immunoglobulin G
Immunoglobulins
Incidence
Medical ethics
Multiplexing
Neisseria meningitidis
Population studies
Quadrivalent meningococcal vaccine
Research ethics
Teenagers
Tetanus
Vaccination
Vaccines
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Summary:Highlights • MenACWY-TT vaccine induces robust primary responses against meningococcal serogroups A, W and Y. • 94% of the participants maintain rSBA titers ≥128 against all three serogroups up to one year. • Compared with 12 and 15 years the 10-year-olds show the lowest SBA titers against MenW after one year.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2017.06.007