Things that could be Mycoplasma pneumoniae

Summary M. pneumoniae infection gives rise to a wide variety of manifestations. The pathogenesis of secondary manifestations is not always known. Some depend on the direct invasion of M. pneumoniae and others on the indirect effect of M. pneumoniae through pathological immune responses, for instance...

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Bibliographic Details
Published in:The Journal of infection 2017-06, Vol.74, p.S95-S100
Main Authors: de Groot, Ruben C.A, Meyer Sauteur, Patrick M, Unger, Wendy W.J, van Rossum, Annemarie M.C
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Cold agglutinin disease
Diagnostic Tests, Routine - methods
Disease Management
Encephalitis
Guillain-Barré syndrome
Humans
Immunologic Factors - therapeutic use
Infectious arthritis
Infectious Disease
Macrolides
Macrolides - therapeutic use
Mycoplasma pneumoniae
Mycoplasma pneumoniae - isolation & purification
Pneumonia, Mycoplasma - diagnosis
Pneumonia, Mycoplasma - drug therapy
Respiratory tract diseases
Serological test
Stevens-Johnson syndrome
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Summary:Summary M. pneumoniae infection gives rise to a wide variety of manifestations. The pathogenesis of secondary manifestations is not always known. Some depend on the direct invasion of M. pneumoniae and others on the indirect effect of M. pneumoniae through pathological immune responses, for instance autoreactive antibodies in Guillain-Barré Syndrome. Diagnosis remains challenging with currently available diagnostic tests, because they do not demonstrate a causal relation due to M. pneumoniae asymptomatic carriage or previous infection. The mainstay of treatment is macrolide antibiotics, but the role of additional immunomodulation therapy is unclear. Knowledge of the pathogenesis of the different manifestations should guide strategies for diagnosis and treatment.
ISSN:0163-4453
1532-2742
DOI:10.1016/S0163-4453(17)30198-6