Brain-derived neurotrophic factor in the infralimbic cortex alleviates inflammatory pain

•Infralimbic BDNF decreases after inflammatory pain.•Infralimbic BDNF infusion alleviates CFA induced thermal hyperalgesia and mechanical allodynia.•Consecutive infralimbic BDNF infusion accelerates recovery process of inflammatory pain. In chronic pain, it has been reported that the medial prefront...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience letters 2017-08, Vol.655, p.7-13
Main Authors: Yue, Lupeng, Ma, Long-Yu, Cui, Shuang, Liu, Feng-Yu, Yi, Ming, Wan, You
Format: Article
Language:English
Subjects:
Animals
Brain derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Brain-Derived Neurotrophic Factor - pharmacology
Hot Temperature
Hyperalgesia - physiopathology
Inflammation - metabolism
Inflammation - physiopathology
Inflammatory pain
Infralimbic cortex
Male
Neurons - metabolism
Pain - metabolism
Pain - physiopathology
Physical Stimulation
Prefrontal cortex
Prefrontal Cortex - metabolism
Proto-Oncogene Proteins c-fos - metabolism
Rats, Sprague-Dawley
Touch
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Infralimbic BDNF decreases after inflammatory pain.•Infralimbic BDNF infusion alleviates CFA induced thermal hyperalgesia and mechanical allodynia.•Consecutive infralimbic BDNF infusion accelerates recovery process of inflammatory pain. In chronic pain, it has been reported that the medial prefrontal cortex (mPFC) takes important regulatory roles, and may change functionally and morphologically in result of chronic pain. Brain-derived neurotrophic factor (BDNF) is well known as a critical modulator of neuronal excitability and synaptic transmission in the central nervous system. The aim of the present study is to investigate the role of BDNF in the infralimbic cortex and the prelimbic cortex of the mPFC in complete Freund’s adjuvant (CFA)-induced inflammatory pain. We found that the BDNF level decreased in the infralimbic cortex, but not in the prelimbic cortex, 3days after the CFA induction of the inflammatory pain. BDNF infusion into bilateral infralimbic cortices to activate neuronal activities could alleviate inflammatory pain and accelerate long-term recovery from pain. In conclusion, BDNF in the infralimbic cortex of the mPFC could accelerate recovery from inflammatory pain.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2017.06.028