Bioactive new withanolides from the cultured soft coral Sinularia brassica

[Display omitted] Continuing study of the ethyl acetate (EtOAc) extract of the cultured soft coral Sinularia brassica afforded five new withanolides, sinubrasolides H–L (1–5). The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxicities of new compou...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2017-08, Vol.27 (15), p.3267-3271
Main Authors: Huang, Chiung-Yao, Ahmed, Atallah F., Su, Jui-Hsin, Sung, Ping-Jyun, Hwang, Tsong-Long, Chiang, Pei-Lun, Dai, Chang-Feng, Liaw, Chih-Chuang, Sheu, Jyh-Horng
Format: Article
Language:English
Subjects:
Animals
Anthozoa - chemistry
Anti-inflammatory activity
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Cytochalasin B - immunology
Cytotoxicity
Humans
Models, Molecular
Neoplasms - drug therapy
Neutrophils - drug effects
Pancreatic Elastase - immunology
Sinularia brassica
Soft coral
Superoxides - immunology
Withanolide
Withanolides - chemistry
Withanolides - isolation & purification
Withanolides - pharmacology
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Summary:[Display omitted] Continuing study of the ethyl acetate (EtOAc) extract of the cultured soft coral Sinularia brassica afforded five new withanolides, sinubrasolides H–L (1–5). The structures of the new compounds were elucidated on the basis of spectroscopic analysis. The cytotoxicities of new compounds 1–5 and a known compound sinubrasolide A (6) against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of compounds 1–6 were evaluated by measuring their ability to suppress N-formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release in human neutrophils.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2017.06.029