In pregnancy increased maternal STAI trait stress score shows decreased insulin sensitivity and increased stress hormones

Highlights • Women with higher STAI trait scores (≥40) had greater serum cortisol and CRH concentrations. • Women with higher STAI trait scores (≥40) had lower insulin sensitivity index values (ISI). • CRH concentrations correlated positively with maternal STAI state score, HOMAR (insulin resistance...

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Published in:Psychoneuroendocrinology 2017-10, Vol.84, p.11-16
Main Authors: Valsamakis, Georgios, Papatheodorou, Dimitrios C, Chalarakis, Nikolaos, Vrachnis, N, Sidiropoulou, Elpida J, Manolikaki, Maria, Mantzou, Aimilia, Margeli, Alexandra, Papassotiriou, Ioannis, Chrousos, George P, Mastorakos, George
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Adrenocorticotropic Hormone - metabolism
Adult
Anxiety - metabolism
Anxiety - psychology
Corticotropin-Releasing Hormone - analysis
Corticotropin-Releasing Hormone - blood
Cortisol
CRH
Endocrinology & Metabolism
Female
Fetus - metabolism
Humans
Hydrocortisone - analysis
Hydrocortisone - blood
Hypothalamo-Hypophyseal System - metabolism
Insulin - metabolism
Insulin Resistance - physiology
Insulin sensitivity
Long-term stress
Pituitary-Adrenal System - metabolism
Placenta - metabolism
Pregnancy
Pregnancy - metabolism
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Psychiatry
Stress, Psychological - complications
Stress, Psychological - metabolism
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Summary:Highlights • Women with higher STAI trait scores (≥40) had greater serum cortisol and CRH concentrations. • Women with higher STAI trait scores (≥40) had lower insulin sensitivity index values (ISI). • CRH concentrations correlated positively with maternal STAI state score, HOMAR (insulin resistance), 1st and 2nd phase insulin secretion and negatively with ISI. • STAI state score correlated positively with HOMAR.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2017.06.008