Next generation sequencing of oral microbiota in Type 2 diabetes mellitus prior to and after neem stick usage and correlation with serum monocyte chemoattractant -1

Highlights • To our knowledge, this is the first study to profile oral microbiota in T2DM and healthy controls. • The study provides evidence for the decrease of bacterial counts in saliva after the use of neem using NGS. • Reduction in serum MCP-1 a pro inflammatory cytokine levels also provides su...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2017-08, Vol.130, p.204-210
Main Authors: Anbalagan, Rubini, Srikanth, Padma, Mani, Monika, Barani, Ramya, Seshadri, Krishna G, Janarthanan, R
Format: Article
Language:English
Subjects:
16s rRNA
Adult
Aged
Chemokine CCL2 - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - microbiology
Endocrinology & Metabolism
Female
Glycerides - therapeutic use
High-Throughput Nucleotide Sequencing - methods
Humans
Male
Microbiota - drug effects
Middle Aged
Mouth - microbiology
Next generation sequencing
Oral microbiota
RNA, Ribosomal, 16S - metabolism
Saliva - microbiology
Serum monocyte chemoattractant-1
T2DM
Terpenes - therapeutic use
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Summary:Highlights • To our knowledge, this is the first study to profile oral microbiota in T2DM and healthy controls. • The study provides evidence for the decrease of bacterial counts in saliva after the use of neem using NGS. • Reduction in serum MCP-1 a pro inflammatory cytokine levels also provides supportive evidence. • This preliminary report suggests that there is a lack of diversity in the oral microbiota of T2DM and healthy non-diabetic controls.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2017.06.009