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Next generation sequencing of oral microbiota in Type 2 diabetes mellitus prior to and after neem stick usage and correlation with serum monocyte chemoattractant -1
Highlights • To our knowledge, this is the first study to profile oral microbiota in T2DM and healthy controls. • The study provides evidence for the decrease of bacterial counts in saliva after the use of neem using NGS. • Reduction in serum MCP-1 a pro inflammatory cytokine levels also provides su...
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| Published in: | Diabetes research and clinical practice 2017-08, Vol.130, p.204-210 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c420t-ffbe8acca60303f2f10495626b398ab936f0336bb10d710604e6221acc4071343 |
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| cites | cdi_FETCH-LOGICAL-c420t-ffbe8acca60303f2f10495626b398ab936f0336bb10d710604e6221acc4071343 |
| container_end_page | 210 |
| container_issue | |
| container_start_page | 204 |
| container_title | Diabetes research and clinical practice |
| container_volume | 130 |
| creator | Anbalagan, Rubini Srikanth, Padma Mani, Monika Barani, Ramya Seshadri, Krishna G Janarthanan, R |
| description | Highlights • To our knowledge, this is the first study to profile oral microbiota in T2DM and healthy controls. • The study provides evidence for the decrease of bacterial counts in saliva after the use of neem using NGS. • Reduction in serum MCP-1 a pro inflammatory cytokine levels also provides supportive evidence. • This preliminary report suggests that there is a lack of diversity in the oral microbiota of T2DM and healthy non-diabetic controls. |
| doi_str_mv | 10.1016/j.diabres.2017.06.009 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0168-8227 |
| ispartof | Diabetes research and clinical practice, 2017-08, Vol.130, p.204-210 |
| issn | 0168-8227 1872-8227 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | 16s rRNA Adult Aged Chemokine CCL2 - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - microbiology Endocrinology & Metabolism Female Glycerides - therapeutic use High-Throughput Nucleotide Sequencing - methods Humans Male Microbiota - drug effects Middle Aged Mouth - microbiology Next generation sequencing Oral microbiota RNA, Ribosomal, 16S - metabolism Saliva - microbiology Serum monocyte chemoattractant-1 T2DM Terpenes - therapeutic use |
| title | Next generation sequencing of oral microbiota in Type 2 diabetes mellitus prior to and after neem stick usage and correlation with serum monocyte chemoattractant -1 |
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