Silver-catalyzed [3 + 2] domino reaction: an efficient strategy to synthesize imidazole-5-carbaldehydes

An unprecedented regioselective silver-catalyzed [3 + 2] domino reaction of amidines and ynals for the formation of C-N bonds has been developed. The reaction provided a new route to prepare imidazole-5-carbaldehydes which are important intermediates for the construction of fine chemicals. The react...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2017-08, Vol.15 (31), p.6463-6466
Main Authors: Wang, Changcheng, Jiang, Hangqi, Chen, Weifeng, Dong, Jun, Chen, Zhengwang, Cao, Hua
Format: Article
Language:English
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Summary:An unprecedented regioselective silver-catalyzed [3 + 2] domino reaction of amidines and ynals for the formation of C-N bonds has been developed. The reaction provided a new route to prepare imidazole-5-carbaldehydes which are important intermediates for the construction of fine chemicals. The reaction proceeds smoothly with a broad range of substrates to give imidazoles in good yields.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob01242j