Expeditious synthesis of pyrano[2,3,4-de]quinolines via Rh(iii)-catalyzed cascade C-H activation/annulation/lactonization of quinolin-4-ol with alkynes

Rh(iii)-catalyzed cascade C-H activation/annulation/lactonization of quinoline-4-ols and alkynes has been reported. A broad range of tetracyclic pyrano[2,3,4-de]quinolines have been prepared in one-step with good functional group tolerance, excellent site selectivity, and high efficiency.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-07, Vol.53 (55), p.7824-7827
Main Authors: Liao, Gang, Song, Hong, Yin, Xue-Song, Shi, Bing-Feng
Format: Article
Language:English
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Summary:Rh(iii)-catalyzed cascade C-H activation/annulation/lactonization of quinoline-4-ols and alkynes has been reported. A broad range of tetracyclic pyrano[2,3,4-de]quinolines have been prepared in one-step with good functional group tolerance, excellent site selectivity, and high efficiency.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc04113f