The interbranchial lymphoid tissue likely contributes to immune tolerance and defense in the gills of Atlantic salmon

Central and peripheral immune tolerance is together with defense mechanisms a hallmark of all lymphoid tissues. In fish, such tolerance is especially important in the gills, where the intimate contact between gill tissue and the aqueous environment would otherwise lead to continual immune stimulatio...

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Bibliographic Details
Published in:Developmental and comparative immunology 2017-11, Vol.76, p.247-254
Main Authors: Aas, Ida Bergva, Austbø, Lars, Falk, Knut, Hordvik, Ivar, Koppang, Erling Olaf
Format: Article
Language:English
Subjects:
Adipocytes
AIRE protein
Animal tissues
Animals
Antigens
Branchial Region - physiology
Central Tolerance
Defense mechanisms
Fish
Fish Diseases - immunology
Fish Proteins - genetics
Fish Proteins - metabolism
Forkhead protein
Forkhead Transcription Factors - genetics
Forkhead Transcription Factors - metabolism
Foxp3 protein
Gene expression
Gene regulation
Genes
Gills
Gills - physiology
Homeostasis
Immunological tolerance
Immunoregulation
Immunosuppression
Intestine
Kidneys
Lymphocytes
Lymphocytes T
Lymphoid tissue
Lymphoid Tissue - physiology
Peripheral Tolerance
Salmo salar
Salmo salar - immunology
Salmon
T-Lymphocytes, Regulatory - immunology
Thymus
Transcription
Transcriptome
Virus Diseases - immunology
Viruses
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Summary:Central and peripheral immune tolerance is together with defense mechanisms a hallmark of all lymphoid tissues. In fish, such tolerance is especially important in the gills, where the intimate contact between gill tissue and the aqueous environment would otherwise lead to continual immune stimulation by innocuous antigens. In this paper, we focus on the expression of genes associated with immune regulation by the interbranchial lymphoid tissue (ILT) in an attempt to understand its role in maintaining immune homeostasis. Both healthy and virus-challenged fish were investigated, and transcript levels were examined from laser-dissected ILT, gills, head kidney and intestine. Lack of Aire expression in the ILT excluded its involvement in central tolerance and any possibility of its being an analogue to the thymus. On the other hand, the ILT appears to participate in peripheral immune tolerance due to its relatively high expression of forkhead box protein 3 (Foxp3) and other genes associated with regulatory T cells (Tregs) and immune suppression.
ISSN:0145-305X
1879-0089
DOI:10.1016/j.dci.2017.06.013