Association of matrix γ-carboxyglutamic acid protein levels with insulin resistance and Lp(a) in diabetes: A cross-sectional study

Highlights • Diabetes coexisting with chronic kidney disease is associated with elevated MGP levels. • A positive association between MGP and both Lp(a) and HOMA IR levels was found. • Potential association of Lp(a) and MGP with atherosclerosis & vascular calcification.

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Bibliographic Details
Published in:Diabetes research and clinical practice 2017-08, Vol.130, p.252-257
Main Authors: Antonopoulos, Stavros, Mylonopoulou, Maria, Angelidi, Angeliki M, Kousoulis, Antonis A, Tentolouris, Nicholas
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis - blood
Atherosclerosis - pathology
Calcium-Binding Proteins - blood
Chronic kidney disease
Cross-Sectional Studies
Diabetes mellitus type 2
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - pathology
Endocrinology & Metabolism
Extracellular Matrix Proteins - blood
Female
Humans
Insulin Resistance
Lipoprotein(a)
Lipoprotein(a) - blood
Male
Matrix Gla Protein
Matrix γ-carboxyglutamic acid protein (MGP)
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - pathology
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Summary:Highlights • Diabetes coexisting with chronic kidney disease is associated with elevated MGP levels. • A positive association between MGP and both Lp(a) and HOMA IR levels was found. • Potential association of Lp(a) and MGP with atherosclerosis & vascular calcification.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2017.06.015