FKBP5 Moderation of the Relationship between Childhood Trauma and Maladaptive Emotion Regulation Strategies in Adolescents

Highlights • This study examined the G × E on transdiagnostic risk factors of psychopathology. • FKBP5 × childhood trauma predicted rumination and catastrophizing in adolescents. • CATT carriers exposed to trauma endorsed the highest rumination and catastrophizing. • Findings suggest mechanisms for...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2017-10, Vol.84, p.61-65
Main Authors: Halldorsdottir, Thorhildur, de Matos, Ana Paula Soares, Awaloff, Yvonne, Arnarson, Eiríkur Örn, Craighead, W. Edward, Binder, Elisabeth B
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Adult Survivors of Child Abuse - psychology
Catastrophization - genetics
Catastrophization - psychology
Catastrophizing
Childhood trauma
Emotions - physiology
Endocrinology & Metabolism
Female
FKBP5
Gene-Environment Interaction
Genetic Variation
Genotype
Haplotypes - genetics
Humans
Life Change Events
Linkage Disequilibrium
Male
Polymorphism, Single Nucleotide
Psychiatry
Psychopathology - methods
Risk Factors
Rumination
Rumination, Cognitive - physiology
Tacrolimus Binding Proteins - genetics
Tacrolimus Binding Proteins - metabolism
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Summary:Highlights • This study examined the G × E on transdiagnostic risk factors of psychopathology. • FKBP5 × childhood trauma predicted rumination and catastrophizing in adolescents. • CATT carriers exposed to trauma endorsed the highest rumination and catastrophizing. • Findings suggest mechanisms for the vulnerability of CATT carriers to psychopathology
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2017.06.012