Patients with paediatric-onset multiple sclerosis are at higher risk of cognitive impairment in adulthood: An Italian collaborative study

Background: Patients with paediatric-onset multiple sclerosis (POMS) could be at an increased risk for cognitive impairment (CI), given the potential harmful effects of disease activity in neurodevelopment. However, there is scarce information on their long-term cognitive outcomes. Objective: To com...

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Bibliographic Details
Published in:Multiple sclerosis 2018-08, Vol.24 (9), p.1234-1242
Main Authors: Ruano, Luis, Branco, Mariana, Portaccio, Emilio, Goretti, Benedetta, Niccolai, Claudia, Patti, Francesco, Chisari, Clara, Gallo, Paolo, Grossi, Paola, Ghezzi, Angelo, Roscio, Marco, Mattioli, Flavia, Stampatori, Chiara, Simone, Marta, Viterbo, Rosa Gemma, Amato, Maria Pia
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Child
Cognitive ability
Cognitive Dysfunction - epidemiology
Cognitive Dysfunction - etiology
Female
Humans
Information processing
Italy - epidemiology
Male
Multiple sclerosis
Multiple Sclerosis - etiology
Multiple Sclerosis - psychology
Neurodevelopmental disorders
Prevalence
Processing speed
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Summary:Background: Patients with paediatric-onset multiple sclerosis (POMS) could be at an increased risk for cognitive impairment (CI), given the potential harmful effects of disease activity in neurodevelopment. However, there is scarce information on their long-term cognitive outcomes. Objective: To compare the prevalence and profile of CI between adults with a history of POMS and those with classic, adult-onset multiple sclerosis (AOMS). Methods: Cognitive performance was assessed through the Brief Repeatable Battery (BRB) and the Stroop Test in consecutive patients referred to six Italian MS centres. CI was defined as impairment in ⩾2 cognitive domains. Results: In all, 119 patients with POMS and 712 with AOMS were included in this analysis. The prevalence of CI was 48.0% in AOMS, 44.5% in POMS; with similar neuropsychological profile between the two groups. However, when adjusting for current age, we found a significantly increased risk for CI (odds ratio (OR) = 1.71; p = 0.02) and for impairment in information processing speed (OR = 1.86; p 
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458517717341