Synthesis of 1,2,4-triazine derivatives via [4 + 2] domino annulation reactions in one pot

Simple and efficient [4 + 2] domino annulation reactions have been developed for the synthesis of 1,2,4-triazine derivatives. The strategies exhibit high performance with moderate to high yields, using easily available materials including ketones, aldehydes, alkynes, secondary alcohols and alkenes,...

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Bibliographic Details
Published in:RSC advances 2016, Vol.6 (15), p.12514-12518
Main Authors: Tang, Dong, Wang, Jing, Wu, Ping, Guo, Xin, Li, Ji-Hui, Yang, Sen, Chen, Bao-Hua
Format: Article
Language:English
Subjects:
Alkynes
Cascade chemical reactions
Chemical reactions
Derivatives
Ketones
Organic chemistry
Strategy
Synthesis (chemistry)
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Summary:Simple and efficient [4 + 2] domino annulation reactions have been developed for the synthesis of 1,2,4-triazine derivatives. The strategies exhibit high performance with moderate to high yields, using easily available materials including ketones, aldehydes, alkynes, secondary alcohols and alkenes, representing a powerful tool for the formation of potentially biologically active derivatives.
ISSN:2046-2069
2046-2069
DOI:10.1039/C5RA26638F