Clinical implication of an impaired fasting glucose and prehypertension related to new onset atrial fibrillation in a healthy Asian population without underlying disease: a nationwide cohort study in Korea

For healthy populations without comorbidities, whether prehypertension and impaired fasting glucose (IFG) are associated with new onset atrial fibrillation (AF) is not well known. We included 366 507 subjects (age ≥20 years) not diagnosed with non-valvular AF from the Korean National Health Insuranc...

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Published in:European heart journal 2017-09, Vol.38 (34), p.2599-2607
Main Authors: Lee, Sean S, Ae Kong, Kyoung, Kim, Daehoon, Lim, Yeong-Min, Yang, Pil-Sung, Yi, Jeong-Eun, Kim, Minsuk, Kwon, Kihwan, Bum Pyun, Wook, Joung, Boyoung, Park, Junbeom
Format: Article
Language:English
Subjects:
Adult
Aged
Atrial Fibrillation - ethnology
Atrial Fibrillation - etiology
Blood Glucose - metabolism
Body Mass Index
Cohort Studies
Fasting - blood
Female
Healthy Volunteers
Humans
Life Style
Male
Middle Aged
Prehypertension - complications
Prehypertension - ethnology
Republic of Korea - ethnology
Risk Factors
Young Adult
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Summary:For healthy populations without comorbidities, whether prehypertension and impaired fasting glucose (IFG) are associated with new onset atrial fibrillation (AF) is not well known. We included 366 507 subjects (age ≥20 years) not diagnosed with non-valvular AF from the Korean National Health Insurance Service-National Sample Cohort (NHIS-NSC) from 2003 to 2008. In total, 139 306 subjects diagnosed with AF-related comorbidities were excluded, and a 227 102 healthy population was followed up until 2013. The body mass index (BMI), blood pressure (BP), and fasting blood glucose (BG) level were acquired during National health check-ups. Subjects with IFG [hazard ratio (HR) 1.16, P = 0.017] had a higher AF risk and the diastolic BP (HR 1.11, P = 0.045) was a stronger indicator for an AF incidence than the systolic BP. After dividing the subjects into two mutually exclusive groups, AF incidence was increased dramatically by the combination effect of both prehypertension and an IFG in BMI
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehx316