Loading…
LEI0258 microsatellite variability and its association with humoral and cell mediated immune responses in broiler chickens
•There is no information about MHC genotypes and disease resistance in Ross 308 broiler chicken.•A significant association was observed between LEI0258 and Cell-mediated immune response.•A significant association was observed between LEI0258 and immune response to Infectious bursal disease (IBD).•A...
Saved in:
| Published in: | Molecular immunology 2017-10, Vol.90, p.22-26 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c408t-907018dcdde9735669a9c1346b65afcf0f264093f95e5bd22a61de5132ecab163 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c408t-907018dcdde9735669a9c1346b65afcf0f264093f95e5bd22a61de5132ecab163 |
| container_end_page | 26 |
| container_issue | |
| container_start_page | 22 |
| container_title | Molecular immunology |
| container_volume | 90 |
| creator | Esmailnejad, Atefeh Nikbakht Brujeni, Gholamreza Badavam, Maryam |
| description | •There is no information about MHC genotypes and disease resistance in Ross 308 broiler chicken.•A significant association was observed between LEI0258 and Cell-mediated immune response.•A significant association was observed between LEI0258 and immune response to Infectious bursal disease (IBD).•A significant association was observed between LEI0258 and immune response to Newcastle disease (ND).
Major histocompatibility complex (MHC) has a profound influence on disease resistance or susceptibility, productivity and important economic traits in chicken. Association of the MHC with a wide range of immune responses makes it a valuable predictive factor for the disease pathogenesis and outcome. The tandem repeat LEI0258 is a genetic marker which is located within the B locus of chicken MHC and strongly associated with serologically defined haplotypes. LEI0258 microsatellite marker was applied to investigate the MHC polymorphism in Ross 308 broiler chicken (N=104). Association of LEI0258 alleles with humoral and cell mediated immune responses to Newcastle disease (ND), Infectious bursal disease (IBD) and Avian influenza (AI) vaccines were also examined. LEI0258 polymorphism was determined by PCR-based fragment analysis, and association of LEI0258 alleles with immune responses were evaluated using multivariate regression analysis and GLM procedures. A total of seven alleles ranging from 195 to 448bp were found, including two novel alleles (263 and 362bp) that were unique in Ross 308 broiler population. Association study revealed a significant influence of MHC alleles on humoral and cellular immune responses in Ross population (P |
| doi_str_mv | 10.1016/j.molimm.2017.06.027 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1915342753</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0161589017301992</els_id><sourcerecordid>1915342753</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-907018dcdde9735669a9c1346b65afcf0f264093f95e5bd22a61de5132ecab163</originalsourceid><addsrcrecordid>eNp9kE1v1DAQhi0EokvhHyDkI5eEsRM78QUJVQUqrcQFzpbjTLSzxPFiJ0Xl1-NlC0dOHsnPOx8PY68F1AKEfnesQ5wphFqC6GrQNcjuCduJvpOVEa18ynYFE5XqDVyxFzkfAUCDVs_Zley1lq2AHfu1v70DqXoeyKeY3YrzTCvye5fIDVTqB-6WkdOaucs5enIrxYX_pPXAD1uIyc1_AF-CPOBY_rHgIWwL8oT5FJeMmdPChxRpxsT9gfx3XPJL9mxyc8ZXj-81-_bx9uvN52r_5dPdzYd95Vvo18pAB6If_Tii6RqltXHGi6bVg1Zu8hNMUrdgmskoVMMopdNiRCUaid4NQjfX7O2l7ynFHxvm1QbK53XdgnHLVhihmlZ2qiloe0HPLnLCyZ4SBZcerAB7tm6P9mLdnq1b0LZYL7E3jxO2oSj4F_qruQDvLwCWO-8Jk82ecPFFV0K_2jHS_yf8Bi-ClvQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1915342753</pqid></control><display><type>article</type><title>LEI0258 microsatellite variability and its association with humoral and cell mediated immune responses in broiler chickens</title><source>ScienceDirect Journals</source><creator>Esmailnejad, Atefeh ; Nikbakht Brujeni, Gholamreza ; Badavam, Maryam</creator><creatorcontrib>Esmailnejad, Atefeh ; Nikbakht Brujeni, Gholamreza ; Badavam, Maryam</creatorcontrib><description>•There is no information about MHC genotypes and disease resistance in Ross 308 broiler chicken.•A significant association was observed between LEI0258 and Cell-mediated immune response.•A significant association was observed between LEI0258 and immune response to Infectious bursal disease (IBD).•A significant association was observed between LEI0258 and immune response to Newcastle disease (ND).
Major histocompatibility complex (MHC) has a profound influence on disease resistance or susceptibility, productivity and important economic traits in chicken. Association of the MHC with a wide range of immune responses makes it a valuable predictive factor for the disease pathogenesis and outcome. The tandem repeat LEI0258 is a genetic marker which is located within the B locus of chicken MHC and strongly associated with serologically defined haplotypes. LEI0258 microsatellite marker was applied to investigate the MHC polymorphism in Ross 308 broiler chicken (N=104). Association of LEI0258 alleles with humoral and cell mediated immune responses to Newcastle disease (ND), Infectious bursal disease (IBD) and Avian influenza (AI) vaccines were also examined. LEI0258 polymorphism was determined by PCR-based fragment analysis, and association of LEI0258 alleles with immune responses were evaluated using multivariate regression analysis and GLM procedures. A total of seven alleles ranging from 195 to 448bp were found, including two novel alleles (263 and 362bp) that were unique in Ross 308 broiler population. Association study revealed a significant influence of MHC alleles on humoral and cellular immune responses in Ross population (P<0.05). Alleles 385 and 448bp were associated with increased peripheral blood lymphocyte proliferation response. Alleles 300, 362 and 448bp had a positive effect on immune responses to Infectious bursal disease vaccine, and allele 263bp was significantly correlated with elevated antibody titer against Newcastle disease vaccine. Results obtained from this study confirmed the important role of MHC as a candidate gene marker for immune responses that could be used in genetic improvement of disease-resistant traits and resource conservation in broiler population.</description><identifier>ISSN: 0161-5890</identifier><identifier>EISSN: 1872-9142</identifier><identifier>DOI: 10.1016/j.molimm.2017.06.027</identifier><identifier>PMID: 28662410</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alleles ; Animals ; Birnaviridae Infections - immunology ; Birnaviridae Infections - veterinary ; Birnaviridae Infections - virology ; Broiler chicken ; Cell mediated immune responses ; Cell Proliferation ; Chickens - genetics ; Chickens - immunology ; Genetic Markers - genetics ; Humoral immune responses ; Immunity, Cellular - genetics ; Immunity, Humoral - genetics ; Influenza in Birds - immunology ; Influenza in Birds - virology ; Influenza Vaccines - immunology ; LEI0258 ; Major Histocompatibility Complex - genetics ; Major Histocompatibility Complex - immunology ; MHC ; Microsatellite Repeats - genetics ; Newcastle Disease - immunology ; Newcastle Disease - virology ; Polymorphism, Genetic - genetics ; Viral Vaccines - immunology</subject><ispartof>Molecular immunology, 2017-10, Vol.90, p.22-26</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-907018dcdde9735669a9c1346b65afcf0f264093f95e5bd22a61de5132ecab163</citedby><cites>FETCH-LOGICAL-c408t-907018dcdde9735669a9c1346b65afcf0f264093f95e5bd22a61de5132ecab163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28662410$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Esmailnejad, Atefeh</creatorcontrib><creatorcontrib>Nikbakht Brujeni, Gholamreza</creatorcontrib><creatorcontrib>Badavam, Maryam</creatorcontrib><title>LEI0258 microsatellite variability and its association with humoral and cell mediated immune responses in broiler chickens</title><title>Molecular immunology</title><addtitle>Mol Immunol</addtitle><description>•There is no information about MHC genotypes and disease resistance in Ross 308 broiler chicken.•A significant association was observed between LEI0258 and Cell-mediated immune response.•A significant association was observed between LEI0258 and immune response to Infectious bursal disease (IBD).•A significant association was observed between LEI0258 and immune response to Newcastle disease (ND).
Major histocompatibility complex (MHC) has a profound influence on disease resistance or susceptibility, productivity and important economic traits in chicken. Association of the MHC with a wide range of immune responses makes it a valuable predictive factor for the disease pathogenesis and outcome. The tandem repeat LEI0258 is a genetic marker which is located within the B locus of chicken MHC and strongly associated with serologically defined haplotypes. LEI0258 microsatellite marker was applied to investigate the MHC polymorphism in Ross 308 broiler chicken (N=104). Association of LEI0258 alleles with humoral and cell mediated immune responses to Newcastle disease (ND), Infectious bursal disease (IBD) and Avian influenza (AI) vaccines were also examined. LEI0258 polymorphism was determined by PCR-based fragment analysis, and association of LEI0258 alleles with immune responses were evaluated using multivariate regression analysis and GLM procedures. A total of seven alleles ranging from 195 to 448bp were found, including two novel alleles (263 and 362bp) that were unique in Ross 308 broiler population. Association study revealed a significant influence of MHC alleles on humoral and cellular immune responses in Ross population (P<0.05). Alleles 385 and 448bp were associated with increased peripheral blood lymphocyte proliferation response. Alleles 300, 362 and 448bp had a positive effect on immune responses to Infectious bursal disease vaccine, and allele 263bp was significantly correlated with elevated antibody titer against Newcastle disease vaccine. Results obtained from this study confirmed the important role of MHC as a candidate gene marker for immune responses that could be used in genetic improvement of disease-resistant traits and resource conservation in broiler population.</description><subject>Alleles</subject><subject>Animals</subject><subject>Birnaviridae Infections - immunology</subject><subject>Birnaviridae Infections - veterinary</subject><subject>Birnaviridae Infections - virology</subject><subject>Broiler chicken</subject><subject>Cell mediated immune responses</subject><subject>Cell Proliferation</subject><subject>Chickens - genetics</subject><subject>Chickens - immunology</subject><subject>Genetic Markers - genetics</subject><subject>Humoral immune responses</subject><subject>Immunity, Cellular - genetics</subject><subject>Immunity, Humoral - genetics</subject><subject>Influenza in Birds - immunology</subject><subject>Influenza in Birds - virology</subject><subject>Influenza Vaccines - immunology</subject><subject>LEI0258</subject><subject>Major Histocompatibility Complex - genetics</subject><subject>Major Histocompatibility Complex - immunology</subject><subject>MHC</subject><subject>Microsatellite Repeats - genetics</subject><subject>Newcastle Disease - immunology</subject><subject>Newcastle Disease - virology</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Viral Vaccines - immunology</subject><issn>0161-5890</issn><issn>1872-9142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQhi0EokvhHyDkI5eEsRM78QUJVQUqrcQFzpbjTLSzxPFiJ0Xl1-NlC0dOHsnPOx8PY68F1AKEfnesQ5wphFqC6GrQNcjuCduJvpOVEa18ynYFE5XqDVyxFzkfAUCDVs_Zley1lq2AHfu1v70DqXoeyKeY3YrzTCvye5fIDVTqB-6WkdOaucs5enIrxYX_pPXAD1uIyc1_AF-CPOBY_rHgIWwL8oT5FJeMmdPChxRpxsT9gfx3XPJL9mxyc8ZXj-81-_bx9uvN52r_5dPdzYd95Vvo18pAB6If_Tii6RqltXHGi6bVg1Zu8hNMUrdgmskoVMMopdNiRCUaid4NQjfX7O2l7ynFHxvm1QbK53XdgnHLVhihmlZ2qiloe0HPLnLCyZ4SBZcerAB7tm6P9mLdnq1b0LZYL7E3jxO2oSj4F_qruQDvLwCWO-8Jk82ecPFFV0K_2jHS_yf8Bi-ClvQ</recordid><startdate>201710</startdate><enddate>201710</enddate><creator>Esmailnejad, Atefeh</creator><creator>Nikbakht Brujeni, Gholamreza</creator><creator>Badavam, Maryam</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201710</creationdate><title>LEI0258 microsatellite variability and its association with humoral and cell mediated immune responses in broiler chickens</title><author>Esmailnejad, Atefeh ; Nikbakht Brujeni, Gholamreza ; Badavam, Maryam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-907018dcdde9735669a9c1346b65afcf0f264093f95e5bd22a61de5132ecab163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Birnaviridae Infections - immunology</topic><topic>Birnaviridae Infections - veterinary</topic><topic>Birnaviridae Infections - virology</topic><topic>Broiler chicken</topic><topic>Cell mediated immune responses</topic><topic>Cell Proliferation</topic><topic>Chickens - genetics</topic><topic>Chickens - immunology</topic><topic>Genetic Markers - genetics</topic><topic>Humoral immune responses</topic><topic>Immunity, Cellular - genetics</topic><topic>Immunity, Humoral - genetics</topic><topic>Influenza in Birds - immunology</topic><topic>Influenza in Birds - virology</topic><topic>Influenza Vaccines - immunology</topic><topic>LEI0258</topic><topic>Major Histocompatibility Complex - genetics</topic><topic>Major Histocompatibility Complex - immunology</topic><topic>MHC</topic><topic>Microsatellite Repeats - genetics</topic><topic>Newcastle Disease - immunology</topic><topic>Newcastle Disease - virology</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Viral Vaccines - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Esmailnejad, Atefeh</creatorcontrib><creatorcontrib>Nikbakht Brujeni, Gholamreza</creatorcontrib><creatorcontrib>Badavam, Maryam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Esmailnejad, Atefeh</au><au>Nikbakht Brujeni, Gholamreza</au><au>Badavam, Maryam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LEI0258 microsatellite variability and its association with humoral and cell mediated immune responses in broiler chickens</atitle><jtitle>Molecular immunology</jtitle><addtitle>Mol Immunol</addtitle><date>2017-10</date><risdate>2017</risdate><volume>90</volume><spage>22</spage><epage>26</epage><pages>22-26</pages><issn>0161-5890</issn><eissn>1872-9142</eissn><abstract>•There is no information about MHC genotypes and disease resistance in Ross 308 broiler chicken.•A significant association was observed between LEI0258 and Cell-mediated immune response.•A significant association was observed between LEI0258 and immune response to Infectious bursal disease (IBD).•A significant association was observed between LEI0258 and immune response to Newcastle disease (ND).
Major histocompatibility complex (MHC) has a profound influence on disease resistance or susceptibility, productivity and important economic traits in chicken. Association of the MHC with a wide range of immune responses makes it a valuable predictive factor for the disease pathogenesis and outcome. The tandem repeat LEI0258 is a genetic marker which is located within the B locus of chicken MHC and strongly associated with serologically defined haplotypes. LEI0258 microsatellite marker was applied to investigate the MHC polymorphism in Ross 308 broiler chicken (N=104). Association of LEI0258 alleles with humoral and cell mediated immune responses to Newcastle disease (ND), Infectious bursal disease (IBD) and Avian influenza (AI) vaccines were also examined. LEI0258 polymorphism was determined by PCR-based fragment analysis, and association of LEI0258 alleles with immune responses were evaluated using multivariate regression analysis and GLM procedures. A total of seven alleles ranging from 195 to 448bp were found, including two novel alleles (263 and 362bp) that were unique in Ross 308 broiler population. Association study revealed a significant influence of MHC alleles on humoral and cellular immune responses in Ross population (P<0.05). Alleles 385 and 448bp were associated with increased peripheral blood lymphocyte proliferation response. Alleles 300, 362 and 448bp had a positive effect on immune responses to Infectious bursal disease vaccine, and allele 263bp was significantly correlated with elevated antibody titer against Newcastle disease vaccine. Results obtained from this study confirmed the important role of MHC as a candidate gene marker for immune responses that could be used in genetic improvement of disease-resistant traits and resource conservation in broiler population.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>28662410</pmid><doi>10.1016/j.molimm.2017.06.027</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-5890 |
| ispartof | Molecular immunology, 2017-10, Vol.90, p.22-26 |
| issn | 0161-5890 1872-9142 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1915342753 |
| source | ScienceDirect Journals |
| subjects | Alleles Animals Birnaviridae Infections - immunology Birnaviridae Infections - veterinary Birnaviridae Infections - virology Broiler chicken Cell mediated immune responses Cell Proliferation Chickens - genetics Chickens - immunology Genetic Markers - genetics Humoral immune responses Immunity, Cellular - genetics Immunity, Humoral - genetics Influenza in Birds - immunology Influenza in Birds - virology Influenza Vaccines - immunology LEI0258 Major Histocompatibility Complex - genetics Major Histocompatibility Complex - immunology MHC Microsatellite Repeats - genetics Newcastle Disease - immunology Newcastle Disease - virology Polymorphism, Genetic - genetics Viral Vaccines - immunology |
| title | LEI0258 microsatellite variability and its association with humoral and cell mediated immune responses in broiler chickens |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T01%3A48%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=LEI0258%20microsatellite%20variability%20and%20its%20association%20with%20humoral%20and%20cell%20mediated%20immune%20responses%20in%20broiler%20chickens&rft.jtitle=Molecular%20immunology&rft.au=Esmailnejad,%20Atefeh&rft.date=2017-10&rft.volume=90&rft.spage=22&rft.epage=26&rft.pages=22-26&rft.issn=0161-5890&rft.eissn=1872-9142&rft_id=info:doi/10.1016/j.molimm.2017.06.027&rft_dat=%3Cproquest_cross%3E1915342753%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c408t-907018dcdde9735669a9c1346b65afcf0f264093f95e5bd22a61de5132ecab163%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1915342753&rft_id=info:pmid/28662410&rfr_iscdi=true |