Diabetic nephropathy: serum miR-9 confers a poor prognosis in and is associated with level changes of vascular endothelial growth factor and pigment epithelium-derived factor

• Published in: Biotechnology letters 2017-10, Vol.39 (10), p.1583-1590
• Main Authors: Xiao, Yanxin, Guo, Shuqin, Zhang, Yunliang, Bian, Zhiying, Jia, Liyan, Hu, Yanyun, Chen, Jie, Yin, Chao, Li, Ning, Zhang, Dongxun, Zhao, Xincui, Wang, Jun
• Format: Article
• Language: English
• Subjects: Applied Microbiology; Biochemistry; Biomedical and Life Sciences; Biotechnology; Cholesterol; Correlation analysis; Creatinine; Diabetes; Diabetes mellitus; Diabetic nephropathy; Epithelium; Fasting; Fibrinogen; Glucose; Hemoglobin; Insulin; Life Sciences; Lipids; Microbiology; MicroRNAs; Molecular modelling; Nephropathy; Original Research Paper; Pigment epithelium-derived factor; Prognosis; Risk analysis; Risk factors; Serum levels; Vascular endothelial growth factor
• ISSN: 0141-5492; 1573-6776
• DOI: 10.1007/s10529-017-2390-6

Objective To investigate the relationship between the serum level of miR-9 and the progression of diabetic nephropathy (DN) and related molecular mechanisms. Results Thirty-five healthy subjects and 140 DN patients were divided into five groups: control, DN I–II, DN III, DN IV and DN V. Serum level of miR-9 was measured by real-time qPCR. Serum levels of vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF) lipids, fasting glucose, insulin, hemoglobin A1c (HBA1c), creatinine, fibrinogen and insulin resistance (HOMA-IR) were also measured. The results show that the levels of miR-9, PEDF and VEGF are increased with DN progression ( P