Cloning, expression and functional characterization of a D-superfamily conotoxin Lt28.1 with previously undescribed cysteine pattern

•7 novel D-superfamily conotoxins with new cysteine framework were cloned from Conus litteratus.•They had low structural similarity (

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2017-08, Vol.94, p.64-70
Main Authors: Lu, Jianbo, Zhang, Kejun, Wang, Shuo, Sun, Ting, Yu, Shuo, Dai, Qiuyun, Liu, Zhuguo
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Cloning
Cloning, Molecular
Conotoxins - genetics
Conotoxins - metabolism
Conus Snail - chemistry
Conus Snail - metabolism
Expression
Phylogeny
Pichia - genetics
Pichia pastoris
Sequence Analysis, Protein
α9α10 nAChRs
αD-conotoxins
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Description
Summary:•7 novel D-superfamily conotoxins with new cysteine framework were cloned from Conus litteratus.•They had low structural similarity (
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2017.06.008