Loading…

Acute painful autoimmune neuropathy: A variant of Guillain‐Barré syndrome

ABSTRACT Introduction We present a painful small‐fiber neuropathy variant of Guillain‐Barré syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation. Methods Two patients received intravenous immunoglobulin, one corticosteroids. Results The patients...

Full description

Saved in:
Bibliographic Details
Published in:Muscle & nerve 2018-02, Vol.57 (2), p.320-324
Main Authors: Yuki, Nobuhiro, Chan, Amanda C., Wong, Anna Hiu Yi, Inoue, Takayuki, Yokai, Masafumi, Kurihara, Takashi, Devaux, JérôMe J., Wilder‐Smith, Einar
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Introduction We present a painful small‐fiber neuropathy variant of Guillain‐Barré syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation. Methods Two patients received intravenous immunoglobulin, one corticosteroids. Results The patients subsequently improved. Immunoglobulin G (IgG) antibodies in their acute phase sera strongly bound to murine small nerve fibers, and the binding disappeared during the convalescent phase. Serum transfer to a murine nociceptive model induced transient alteration in thermal pain responses. Discussion Our case series suggest that an acute transient immune response can be directed against small nerve fibers, and that patients so affected can exhibit features of Guillain‐Barré syndrome. Muscle Nerve 57: 320–324, 2018
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.25738