Loading…
Acute painful autoimmune neuropathy: A variant of Guillain‐Barré syndrome
ABSTRACT Introduction We present a painful small‐fiber neuropathy variant of Guillain‐Barré syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation. Methods Two patients received intravenous immunoglobulin, one corticosteroids. Results The patients...
Saved in:
Published in: | Muscle & nerve 2018-02, Vol.57 (2), p.320-324 |
---|---|
Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | ABSTRACT
Introduction
We present a painful small‐fiber neuropathy variant of Guillain‐Barré syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation.
Methods
Two patients received intravenous immunoglobulin, one corticosteroids.
Results
The patients subsequently improved. Immunoglobulin G (IgG) antibodies in their acute phase sera strongly bound to murine small nerve fibers, and the binding disappeared during the convalescent phase. Serum transfer to a murine nociceptive model induced transient alteration in thermal pain responses.
Discussion
Our case series suggest that an acute transient immune response can be directed against small nerve fibers, and that patients so affected can exhibit features of Guillain‐Barré syndrome. Muscle Nerve 57: 320–324, 2018 |
---|---|
ISSN: | 0148-639X 1097-4598 |
DOI: | 10.1002/mus.25738 |