Novel sequence variants of viral hexon and fibre genes in two dogs with canine adenovirus type 1-associated disease

• Published in: The veterinary journal (1997) 2017-05, Vol.223, p.73-75
• Main Authors: Balboni, A., Dondi, F., Agnoli, C., Verin, R., Gruarin, M., Morini, M., Battilani, M.
• Format: Article
• Language: English
• Subjects: Adenoviridae Infections - veterinary; Adenoviridae Infections - virology; Adenoviruses, Canine - genetics; Amino Acid Sequence; Animals; Anterior uveitis; Base Sequence; Canine adenovirus type 1; Capsid Proteins - chemistry; Capsid Proteins - genetics; Dogs; Eye Diseases - veterinary; Eye Diseases - virology; Genetic Variation - genetics; Hepatitis, Infectious Canine - virology; Infectious canine hepatitis; Italy; Male; Sequence variants
• ISSN: 1090-0233; 1532-2971
• DOI: 10.1016/j.tvjl.2017.05.011

•Two cases of naturally occurring canine adenovirus type 1 (CAdV-1) infection in domestic dogs are reported.•The diagnosis was confirmed by PCR on tissue samples and rectal swabs.•Clinical, clinicopathological, pathological and virological data are reported.•Hexon and fibre viral gene sequence analyses permitted the identification of novel sequence variants of CAdV-1.•Amino acid position 388 in the hexon protein could differentiate Italian CAdV-1 sequences from those of other regions. There is little information on sequence variation of canine adenovirus type 1 (CAdV-1), the aetiological agent of infectious canine hepatitis (ICH). This study reports hexon and fibre gene sequence variants of CAdV-1 in a dog with systemic ICH and a dog with the ocular form of the disease (‘blue eye’) in Northern Italy in 2013. One of the sequence variants matched a CAdV-1 fox sequence previously detected in Italy.