Topical application of ointment containing 0.5% green tea catechins suppresses tongue oxidative stress in 5-fluorouracil administered rats

Highlights • Oral mucositis is one of the side effect in administration of 5-fluorouracil. • Oxidative stress induced by 5-fluorouracil is an initiator of oral mucositis. • Catechins have antioxidant activity. • Catechins could prevent oxidative stress, with up-regulating Nrf2 signaling pathway....

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Bibliographic Details
Published in:Archives of oral biology 2017-10, Vol.82, p.247-255
Main Authors: Miyai, Hisataka, Maruyama, Takayuki, Tomofuji, Takaaki, Yoneda, Toshiki, Azuma, Tetsuji, Mizuno, Hirofumi, Sugiura, Yoshio, Kobayashi, Terumasa, Ekuni, Daisuke, Morita, Manabu
Format: Article
Language:English
Subjects:
Administration, Topical
Advanced Basic Science
Animals
Antioxidant capacity
Antioxidants - metabolism
Catechin - administration & dosage
Catechin - pharmacology
Chemotherapy
Dentistry
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - metabolism
Fluorouracil - toxicity
Green tea catechin
Male
NF-E2-Related Factor 2 - metabolism
Ointments - administration & dosage
Ointments - pharmacology
Oxidative stress
Oxidative Stress - drug effects
Rats
Rats, Wistar
Tea
Tongue
Tongue - drug effects
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Summary:Highlights • Oral mucositis is one of the side effect in administration of 5-fluorouracil. • Oxidative stress induced by 5-fluorouracil is an initiator of oral mucositis. • Catechins have antioxidant activity. • Catechins could prevent oxidative stress, with up-regulating Nrf2 signaling pathway.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2017.06.025