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Muscle sympathetic nerve activity peaks in the first trimester in healthy pregnancy: a longitudinal case study
Objective and methods Muscle sympathetic nerve activity and baroreflex sensitivity were examined at rest before, during (weeks 6, 11, 17, 22, 25, 33 and 36) and after a normotensive pregnancy. Results Muscle sympathetic nerve activity is elevated during pregnancy with a large peak in the first trime...
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| Published in: | Clinical autonomic research 2017-12, Vol.27 (6), p.401-406 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c372t-c80d30838fcaeef51b46fe7e4064dae3f2d432f205184fef92f17437ef1f048d3 |
| container_end_page | 406 |
| container_issue | 6 |
| container_start_page | 401 |
| container_title | Clinical autonomic research |
| container_volume | 27 |
| creator | Hissen, Sarah L. El Sayed, Khadigeh Macefield, Vaughan G. Brown, Rachael Taylor, Chloe E. |
| description | Objective and methods
Muscle sympathetic nerve activity and baroreflex sensitivity were examined at rest before, during (weeks 6, 11, 17, 22, 25, 33 and 36) and after a normotensive pregnancy.
Results
Muscle sympathetic nerve activity is elevated during pregnancy with a large peak in the first trimester (Δ17 bursts/min) and a secondary peak in the third trimester (Δ11 bursts/min). Cardiac baroreflex sensitivity peaked in the first trimester (10 vs. 6 ms/mmHg pre-pregnancy), whereas sympathetic baroreflex sensitivity was greater throughout.
Interpretation
The increase in sympathetic outflow early in pregnancy cannot be explained by a reduction in baroreflex sensitivity, while the secondary increase in burst frequency in the third trimester may, in part, be explained by the elevated heart rate. |
| doi_str_mv | 10.1007/s10286-017-0439-1 |
| format | article |
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Muscle sympathetic nerve activity and baroreflex sensitivity were examined at rest before, during (weeks 6, 11, 17, 22, 25, 33 and 36) and after a normotensive pregnancy.
Results
Muscle sympathetic nerve activity is elevated during pregnancy with a large peak in the first trimester (Δ17 bursts/min) and a secondary peak in the third trimester (Δ11 bursts/min). Cardiac baroreflex sensitivity peaked in the first trimester (10 vs. 6 ms/mmHg pre-pregnancy), whereas sympathetic baroreflex sensitivity was greater throughout.
Interpretation
The increase in sympathetic outflow early in pregnancy cannot be explained by a reduction in baroreflex sensitivity, while the secondary increase in burst frequency in the third trimester may, in part, be explained by the elevated heart rate.</description><identifier>ISSN: 0959-9851</identifier><identifier>EISSN: 1619-1560</identifier><identifier>DOI: 10.1007/s10286-017-0439-1</identifier><identifier>PMID: 28674869</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adrenergic Fibers - physiology ; Adult ; Baroreceptors ; Baroreflex - physiology ; Blood pressure ; Blood Pressure - physiology ; Cardiology ; Diabetes ; Endocrinology ; Female ; Gastroenterology ; Heart diseases ; Heart rate ; Heart Rate - physiology ; Humans ; Infant, Newborn ; Longitudinal Studies ; Medicine ; Medicine & Public Health ; Muscle, Skeletal - innervation ; Muscle, Skeletal - physiology ; Neurology ; Ophthalmology ; Pregnancy ; Pregnancy Trimester, First - physiology ; Reflexes ; Short Communication ; Sympathetic Nervous System - physiology</subject><ispartof>Clinical autonomic research, 2017-12, Vol.27 (6), p.401-406</ispartof><rights>Springer-Verlag GmbH Germany 2017</rights><rights>Clinical Autonomic Research is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-c80d30838fcaeef51b46fe7e4064dae3f2d432f205184fef92f17437ef1f048d3</citedby><cites>FETCH-LOGICAL-c372t-c80d30838fcaeef51b46fe7e4064dae3f2d432f205184fef92f17437ef1f048d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28674869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hissen, Sarah L.</creatorcontrib><creatorcontrib>El Sayed, Khadigeh</creatorcontrib><creatorcontrib>Macefield, Vaughan G.</creatorcontrib><creatorcontrib>Brown, Rachael</creatorcontrib><creatorcontrib>Taylor, Chloe E.</creatorcontrib><title>Muscle sympathetic nerve activity peaks in the first trimester in healthy pregnancy: a longitudinal case study</title><title>Clinical autonomic research</title><addtitle>Clin Auton Res</addtitle><addtitle>Clin Auton Res</addtitle><description>Objective and methods
Muscle sympathetic nerve activity and baroreflex sensitivity were examined at rest before, during (weeks 6, 11, 17, 22, 25, 33 and 36) and after a normotensive pregnancy.
Results
Muscle sympathetic nerve activity is elevated during pregnancy with a large peak in the first trimester (Δ17 bursts/min) and a secondary peak in the third trimester (Δ11 bursts/min). Cardiac baroreflex sensitivity peaked in the first trimester (10 vs. 6 ms/mmHg pre-pregnancy), whereas sympathetic baroreflex sensitivity was greater throughout.
Interpretation
The increase in sympathetic outflow early in pregnancy cannot be explained by a reduction in baroreflex sensitivity, while the secondary increase in burst frequency in the third trimester may, in part, be explained by the elevated heart rate.</description><subject>Adrenergic Fibers - physiology</subject><subject>Adult</subject><subject>Baroreceptors</subject><subject>Baroreflex - physiology</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Heart diseases</subject><subject>Heart rate</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Longitudinal Studies</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Muscle, Skeletal - innervation</subject><subject>Muscle, Skeletal - physiology</subject><subject>Neurology</subject><subject>Ophthalmology</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First - physiology</subject><subject>Reflexes</subject><subject>Short Communication</subject><subject>Sympathetic Nervous System - physiology</subject><issn>0959-9851</issn><issn>1619-1560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kU1r3DAQhkVoSbZJfkAuRdBLL241kmzJvZXQL0jIJTkLRR7tKvHKW0kO-N9Hy6alFHLSxzzzzvC-hFwA-wSMqc8ZGNddw0A1TIq-gSOygg7qpe3YG7Jifds3vW7hhLzL-YExaLWAY3JSu5TUXb8i8XrObkSal-3Olg2W4GjE9ITUuhKeQlnoDu1jpiHSWqY-pFxoSWGLuWDaf2_QjmVTuYTraKNbvlBLxymuQ5mHEO1Inc11Qn0tZ-Stt2PG85fzlNx9_3Z7-bO5uvnx6_LrVeOE4qVxmg2CaaG9s4i-hXvZeVQoWScHi8LzQQruOWtBS4--5x6UFAo9eCb1IE7Jx4PuLk2_57qq2YbscBxtxGnOBvpqhZagVEU__Ic-THOqa--pjgNvlRaVggPl0pRzQm921QObFgPM7MMwhzBMDcPswzBQe96_KM_3Wxz-dvxxvwL8AORaimtM_4x-VfUZNN2WCQ</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Hissen, Sarah L.</creator><creator>El Sayed, Khadigeh</creator><creator>Macefield, Vaughan G.</creator><creator>Brown, Rachael</creator><creator>Taylor, Chloe E.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20171201</creationdate><title>Muscle sympathetic nerve activity peaks in the first trimester in healthy pregnancy: a longitudinal case study</title><author>Hissen, Sarah L. ; El Sayed, Khadigeh ; Macefield, Vaughan G. ; Brown, Rachael ; Taylor, Chloe E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-c80d30838fcaeef51b46fe7e4064dae3f2d432f205184fef92f17437ef1f048d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adrenergic Fibers - physiology</topic><topic>Adult</topic><topic>Baroreceptors</topic><topic>Baroreflex - physiology</topic><topic>Blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Cardiology</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Heart diseases</topic><topic>Heart rate</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Longitudinal Studies</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Muscle, Skeletal - innervation</topic><topic>Muscle, Skeletal - physiology</topic><topic>Neurology</topic><topic>Ophthalmology</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First - physiology</topic><topic>Reflexes</topic><topic>Short Communication</topic><topic>Sympathetic Nervous System - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hissen, Sarah L.</creatorcontrib><creatorcontrib>El Sayed, Khadigeh</creatorcontrib><creatorcontrib>Macefield, Vaughan G.</creatorcontrib><creatorcontrib>Brown, Rachael</creatorcontrib><creatorcontrib>Taylor, Chloe E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical autonomic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hissen, Sarah L.</au><au>El Sayed, Khadigeh</au><au>Macefield, Vaughan G.</au><au>Brown, Rachael</au><au>Taylor, Chloe E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Muscle sympathetic nerve activity peaks in the first trimester in healthy pregnancy: a longitudinal case study</atitle><jtitle>Clinical autonomic research</jtitle><stitle>Clin Auton Res</stitle><addtitle>Clin Auton Res</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>27</volume><issue>6</issue><spage>401</spage><epage>406</epage><pages>401-406</pages><issn>0959-9851</issn><eissn>1619-1560</eissn><abstract>Objective and methods
Muscle sympathetic nerve activity and baroreflex sensitivity were examined at rest before, during (weeks 6, 11, 17, 22, 25, 33 and 36) and after a normotensive pregnancy.
Results
Muscle sympathetic nerve activity is elevated during pregnancy with a large peak in the first trimester (Δ17 bursts/min) and a secondary peak in the third trimester (Δ11 bursts/min). Cardiac baroreflex sensitivity peaked in the first trimester (10 vs. 6 ms/mmHg pre-pregnancy), whereas sympathetic baroreflex sensitivity was greater throughout.
Interpretation
The increase in sympathetic outflow early in pregnancy cannot be explained by a reduction in baroreflex sensitivity, while the secondary increase in burst frequency in the third trimester may, in part, be explained by the elevated heart rate.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28674869</pmid><doi>10.1007/s10286-017-0439-1</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical autonomic research, 2017-12, Vol.27 (6), p.401-406 |
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| language | eng |
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| source | Springer Link |
| subjects | Adrenergic Fibers - physiology Adult Baroreceptors Baroreflex - physiology Blood pressure Blood Pressure - physiology Cardiology Diabetes Endocrinology Female Gastroenterology Heart diseases Heart rate Heart Rate - physiology Humans Infant, Newborn Longitudinal Studies Medicine Medicine & Public Health Muscle, Skeletal - innervation Muscle, Skeletal - physiology Neurology Ophthalmology Pregnancy Pregnancy Trimester, First - physiology Reflexes Short Communication Sympathetic Nervous System - physiology |
| title | Muscle sympathetic nerve activity peaks in the first trimester in healthy pregnancy: a longitudinal case study |
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