CS-specific modifications of auditory evoked potentials in the behaviorally conditioned rat

• Published in: Brain research 2017-09, Vol.1670, p.235-247
• Main Authors: Leon, Matthew I., Miasnikov, Alexandre A., Wright, Ernest J., Weinberger, Norman M.
• Format: Article
• Language: English
• Subjects: Acoustic Stimulation; Animals; Association Learning - physiology; Associative learning; Auditory Cortex - physiology; Behavior, Animal - physiology; Conditioning, Classical - physiology; Conditioning, Operant; Evoked potential; Evoked Potentials; Evoked Potentials, Auditory - physiology; Heart rate; Learning; Male; Neuronal Plasticity; Neurons - physiology; Plasticity; Primary auditory cortex; Rats; Rats, Sprague-Dawley; Synchronization
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2017.06.030

•Both N1/P2 components of auditory evoked potentials are modified by associative learning.•Associative learning modifies the temporal dynamics of auditory evoked potentials.•Direction of plasticity of auditory evoked potentials depends on CS-US contingency. The current report provides a detailed analysis of the changes in the first two components of the auditory evoked potential (AEP) that accompany associative learning. AEPs were recorded from the primary auditory cortex before and after training sessions. Experimental subjects underwent one (n=5) or two (n=7) days of conditioning in which a tone, serving as a conditioned stimulus (CS), was paired with mild foot shock. Control subjects received one (n=5) or two (n=7) days of exposure to the same stimuli delivered randomly. Only animals receiving paired CS-US training developed a conditioned tachycardia response to the tone. Our analyses demonstrated that both early components of the AEP recorded from the granular layer of the cortex undergo CS-specific associative changes: (1) the first, negative component (occurring ∼21ms following tone onset) was significantly augmented after one and two days of training while maintaining its latency, and (2) the second, positive component (occurring ∼50ms following tone onset) was augmented after two days of training, and showed a significant reduction in latency after one and two days of training. We view these changes as evidence of increased cortical synchronization, thereby lending new insight into the temporal dynamics of neural network activity related to auditory learning.