HLA genotyping as first-line screening tool for coeliac disease in children with juvenile idiopathic arthritis

ObjectivesCoeliac disease (CD) and juvenile idiopathic arthritis (JIA) often coexist. This association warrants assessment for CD in patients with JIA. We evaluated the clinical relevance and cost-effectiveness of human leucocyte antigen (HLA) genotyping in first-line screening for development of CD...

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Bibliographic Details
Published in:Archives of disease in childhood 2017-07, Vol.102 (7), p.607-611
Main Authors: Skrabl-Baumgartner, Andrea, Christine Hauer, Almuthe, Erwa, Wolfgang, Jahnel, Jörg
Format: Article
Language:English
Subjects:
Adolescent
Age of Onset
Antibodies
Antigens
Arthritis
Arthritis, Juvenile - economics
Arthritis, Juvenile - genetics
Arthritis, Juvenile - immunology
Autoantibodies - metabolism
Biopsy
Celiac disease
Celiac Disease - diagnosis
Celiac Disease - economics
Celiac Disease - genetics
Celiac Disease - immunology
Child
Child, Preschool
Children
Children & youth
Complications and side effects
Cost-Benefit Analysis
Early Diagnosis
Environmental Influences
Female
Gastroenterology
Genotype
Genotype & phenotype
Genotypes
Genotyping
Genotyping Techniques - economics
Genotyping Techniques - methods
Guidelines
Health aspects
Histocompatibility antigen HLA
HLA-DQ Antigens - genetics
Humans
Infant
Intestine
Juvenile arthritis
Male
Medical screening
Nutrition
Patients
Prospective Studies
Rheumatoid arthritis
Risk factors
Screening Tests
Statistical Analysis
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Summary:ObjectivesCoeliac disease (CD) and juvenile idiopathic arthritis (JIA) often coexist. This association warrants assessment for CD in patients with JIA. We evaluated the clinical relevance and cost-effectiveness of human leucocyte antigen (HLA) genotyping in first-line screening for development of CD in children with JIA.Patients and interventions95 patients with JIA were screened for CD using CD-specific antibodies. In case of positivity, a small intestinal biopsy was performed to confirm diagnosis. In addition, HLA genotyping was performed. 110 age-matched and sex-matched Caucasian children from the same geographical area served as controls.ResultsCD was diagnosed in 4 of 95 patients with JIA (4.2%), a rate significantly higher compared with controls (p
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2016-311544