Talaramide A, an unusual alkaloid from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1) as an inhibitor of mycobacterial PknG

An unusual alkaloid, talaramide A ( 1 ), was obtained from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1). The structure of 1 was established by analysis of NMR spectroscopic data, X-ray diffraction data, and electronic circular dichroism (ECD) spectra. Talaramide A ( 1 ) is the second exam...

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Bibliographic Details
Published in:New journal of chemistry 2017, Vol.41 (11), p.4273-4276
Main Authors: Chen, Senhua, He, Liqing, Chen, Dongni, Cai, Runlin, Long, Yuhua, Lu, Yongjun, She, Zhigang
Format: Article
Language:English
Subjects:
Mycobacterium
Talaromyces
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Summary:An unusual alkaloid, talaramide A ( 1 ), was obtained from the mangrove endophytic fungus Talaromyces sp. (HZ-YX1). The structure of 1 was established by analysis of NMR spectroscopic data, X-ray diffraction data, and electronic circular dichroism (ECD) spectra. Talaramide A ( 1 ) is the second example of an alkaloid that possesses a unique oxidized tricyclic system. A possible biosynthetic pathway for 1 was proposed. Compound 1 showed promising inhibition of mycobacterial PknG activity with an IC 50 value of 55 μM.
ISSN:1144-0546
1369-9261
DOI:10.1039/C7NJ00059F