Lanthanoplatins: emissive Eu(iii) and Tb(iii) complexes staining nucleoli targeted through Pt-DNA crosslinking

Two highly luminescent water-soluble heterometallic LnPt complexes, [{cis-PtCl(NH ) } Ln(L)(H O)](NO ) (Ln = Eu (1), Tb (2)), have been designed for their selective nucleoli staining through formation of Pt-DNA crosslinks. The complexes showed significant cellular uptake and distinctive nucleoli loc...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017-06, Vol.53 (45), p.6144-6147
Main Authors: Singh, Khushbu, Singh, Swati, Srivastava, Payal, Sivakumar, Sri, Patra, Ashis K
Format: Article
Language:English
Subjects:
Confocal
Crosslinking
Emission
Fluorescence
Localization
Microscopy
Staining
Uptakes
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Summary:Two highly luminescent water-soluble heterometallic LnPt complexes, [{cis-PtCl(NH ) } Ln(L)(H O)](NO ) (Ln = Eu (1), Tb (2)), have been designed for their selective nucleoli staining through formation of Pt-DNA crosslinks. The complexes showed significant cellular uptake and distinctive nucleoli localization through intrinsic emission from Eu or Tb observed through confocal fluorescence microscopy.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc02047c