trans-Polydatin protects the mouse heart against ischemia/reperfusion injury via inhibition of the renin-angiotensin system (RAS) and Rho kinase (ROCK) activity

Recent studies highlighted the protective benefits of a Chinese herb extract from polygonum cuspidatum, trans-polydatin, on cardiac disease. We investigated the therapeutic effect of trans-polydatin on myocardial ischemia/reperfusion (IR) injury and the underlying mechanisms related to the renin-ang...

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Bibliographic Details
Published in:Food & function 2017-06, Vol.8 (6), p.2309-2321
Main Authors: Ming, Dong, Songyan, Liao, Yawen, Chen, Na, Zheng, Jing, Ma, Zhaowen, Xiao, Ye, Liu, Wa, Ding, Jie, Liu
Format: Article
Language:English
Subjects:
Animals
Apoptosis - drug effects
Glucosides - administration & dosage
Glucosides - chemistry
Heart - drug effects
Humans
Ischemia - surgery
Male
Mice
Mice, Inbred C57BL
Myocardial Reperfusion Injury - drug therapy
Myocardial Reperfusion Injury - enzymology
Myocardial Reperfusion Injury - genetics
Myocardial Reperfusion Injury - metabolism
Myocardium - metabolism
Polygonum cuspidatum
Renin-Angiotensin System - drug effects
rho-Associated Kinases - metabolism
Signal Transduction - drug effects
Stilbenes - administration & dosage
Stilbenes - chemistry
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Summary:Recent studies highlighted the protective benefits of a Chinese herb extract from polygonum cuspidatum, trans-polydatin, on cardiac disease. We investigated the therapeutic effect of trans-polydatin on myocardial ischemia/reperfusion (IR) injury and the underlying mechanisms related to the renin-angiotensin system (RAS) and RhoA kinase (ROCK) pathway. Experiments were performed on neonatal rats' ventricular myocytes that were subjected to hypoxia-reoxygenation (simulated IR, SIR) and on adult mice which were subjected to left anterior descending coronary artery occlusion for 45 min followed by a one-week reperfusion. trans-Polydatin significantly increased cell viability and reduced apoptosis in SIR cardiomyocytes. It was also observed to reduce the infarct size and increase the cardiac function in IR mice. trans-Polydatin decreased the expression of angiotensin and inhibited the activities of renin and angiotensin-converting enzyme. Furthermore, trans-polydatin inhibited ROCK activity, especially the angiotensin I receptor-activated ROCK pathway. trans-Polydatin exerts a cardio-protection against myocardial IR injury likely through inhibiting both RAS and the downstream ROCK pathway.
ISSN:2042-6496
2042-650X
DOI:10.1039/c6fo01842d