Longitudinal evaluation of sleep disordered breathing in infants with Prader-Willi syndrome

• Published in: Archives of disease in childhood 2017-07, Vol.102 (7), p.638-638
• Main Authors: Khayat, Abdullah, Narang, Indra, Bin-Hasan, Saadoun, Amin, Reshma, Al-Saleh, Suhail
• Format: Article
• Language: English
• Subjects: Age; Apnea; Care and treatment; Child, Preschool; Children; Endocrine therapy; Female; Genetic Disorders; Growth disorders; Growth hormones; Health aspects; Hospitals; Humans; Infant; Infants; Longitudinal Studies; Male; Observational studies; Oxygen therapy; Pediatrics; Polysomnography; Prader-Willi syndrome; Prader-Willi Syndrome - complications; Prospective Studies; Respiration; Sleep; Sleep apnea; Sleep Apnea Syndromes - etiology; Sleep Apnea, Central - etiology; Sleep deprivation; Sleep disorders; Young Children
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2016-311298

ObjectiveTo evaluate the course of sleep disordered breathing (SDB) in infants with Prader-Willi syndrome (PWS).DesignRetrospective longitudinal observational study.SettingSleep laboratory at The Hospital for Sick Children, Toronto, Canada.PatientsInfants with PWS.Main outcome measuresThe natural history of SDB in infants with PWS within 2 years from baseline assessment.ResultsWe identified 28 (12 male) infants with PWS who had a baseline polysomnography (PSG) at a median age (interquartile (IQR)) of 0.9 (0.5, 1.1) years. The median central apnoea index (CAI) at baseline was 6.6 events/hour (IQR 2.6, 12.1). Of these, 15/28 (53%) infants with PWS were diagnosed with significant central sleep apnoea (CSA) (CAI≥5 events/hour). Median age (IQR) at follow-up PSG was 2.1 (1.5, 2.6) years. The median CAI improved from 6.6 to 2.3 events/hour (p