The role of cone-beam breast-CT for breast cancer detection relative to breast density

• Published in: European radiology 2017-12, Vol.27 (12), p.5185-5195
• Main Authors: Wienbeck, Susanne, Uhlig, Johannes, Luftner-Nagel, Susanne, Zapf, Antonia, Surov, Alexey, von Fintel, Eva, Stahnke, Vera, Lotz, Joachim, Fischer, Uwe
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Breast; Breast - diagnostic imaging; Breast cancer; Breast Density; Breast Neoplasms - diagnosis; Breasts; Computed tomography; Cone-Beam Computed Tomography - methods; Density; Diagnostic Radiology; Diagnostic systems; Double-Blind Method; Female; Follow-Up Studies; Humans; Imaging; Internal Medicine; Interventional Radiology; Lesions; Magnetic Resonance Imaging; Mammography; Mammography - methods; Medicine; Medicine & Public Health; Middle Aged; Neuroradiology; Radiology; Reproducibility of Results; Retrospective Studies; Sensitivity; Ultrasonography, Mammary - methods; Ultrasound
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-017-4911-z

Objectives To evaluate the impact of breast density on the diagnostic accuracy of non-contrast cone-beam breast computed tomography (CBBCT) in comparison to mammography for the detection of breast masses. Methods A retrospective study was conducted from August 2015 to July 2016. Fifty-nine patients (65 breasts, 112 lesions) with BI-RADS, 5th edition 4 or 5 assessment in mammography and/or ultrasound of the breast received an additional non-contrast CBBCT. Independent double blind reading by two radiologists was performed for mammography and CBBCT imaging. Sensitivity, specificity and AUC were compared between the modalities. Results Breast lesions were histologically examined in 85 of 112 lesions (76%). The overall sensitivity for CBBCT (reader 1: 91%, reader 2: 88%) was higher than in mammography (both: 68%, p