Acne

Summary Acne is a chronic disease with a high prevalence among adolescents. Key pathogenetic factors (and their clinical correlates) are increased sebum production (seborrhea), follicular hyperkeratosis (comedones), and perifollicular inflammation (papules and pustules). The disease is modulated by...

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Bibliographic Details
Published in:Journal der Deutschen Dermatologischen Gesellschaft 2017-07, Vol.15 (7), p.709-722
Main Authors: Degitz, Klaus, Ochsendorf, Falk
Format: Article
Language:English
Subjects:
Acne
Adolescents
Androgens
Chronic illnesses
Comedones
Insulin-like growth factor I
Morbidity
Quality of life
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Summary:Summary Acne is a chronic disease with a high prevalence among adolescents. Key pathogenetic factors (and their clinical correlates) are increased sebum production (seborrhea), follicular hyperkeratosis (comedones), and perifollicular inflammation (papules and pustules). The disease is modulated by a variety of endogenous (androgens, IGF‐1, neuroendocrine factors) and exogenous (Propionibacterium acnes, diet, friction, ingredients of medical or cosmetic topical products) triggers. Acne is associated with high morbidity, and even mild manifestations may potentially cause considerable impairment in quality of life. Effective topical and systemic treatments are available. Optimal therapeutic results require continuous patient management over the course of the entire treatment period as well as adjustment of treatment modalities based on symptoms and disease severity.
ISSN:1610-0379
1610-0387
DOI:10.1111/ddg.13278