Functional analysis of Discoidin domain receptor 2 mutation and expression in squamous cell lung cancer

Highlights • Endogenous DDR2 protein expression levels were high in 29% of lung SQCC patients. • A DDR2 mutation (T681I) identified in a lung SQCC clinical sample and the cell line. • Forced expression of DDR2 induced invasion in vitro and metastasis in animal model. • Ectopic expression of DDR2 ind...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-08, Vol.110, p.35-41
Main Authors: Kobayashi-Watanabe, Naomi, Sato, Akemi, Watanabe, Tatsuro, Abe, Tomonori, Nakashima, Chiho, Sueoka, Eisaburo, Kimura, Shinya, Sueoka-Aragane, Naoko
Format: Article
Language:English
Subjects:
Alleles
Animals
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Line, Tumor
Cell Movement - genetics
Cell Proliferation
DDR2
Discoidin Domain Receptor 2 - genetics
Discoidin Domain Receptor 2 - metabolism
Disease Models, Animal
Gene Expression
Hematology, Oncology and Palliative Medicine
Humans
Immunohistochemistry
Lung Neoplasms - genetics
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Lung squamous cell carcinoma
Male
Matrix Metalloproteinase 1 - metabolism
Mice
MMP-1
Mutation
Overexpression
Phosphorylation
Proto-Oncogene Proteins c-jun - metabolism
Pulmonary/Respiratory
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Summary:Highlights • Endogenous DDR2 protein expression levels were high in 29% of lung SQCC patients. • A DDR2 mutation (T681I) identified in a lung SQCC clinical sample and the cell line. • Forced expression of DDR2 induced invasion in vitro and metastasis in animal model. • Ectopic expression of DDR2 induced MMP1 mRNA expression. 　　　　　　　　　 • T681I mutation seems to be an inactivating mutation.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2017.05.017