Body mass index and all-cause mortality among type 2 diabetes mellitus patients: Findings from the 5-year follow-up of the MADIABETES cohort

To analyse the association between body mass index (BMI) and all-cause mortality in a 5-year follow-up study with Spanish type 2 diabetes mellitus (T2DM) patients, seeking gender differences. 3443 T2DM outpatients were studied. At baseline and annually, patients were subjected to anamnesis, a physic...

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Published in:European journal of internal medicine 2017-09, Vol.43, p.46-52
Main Authors: Salinero-Fort, M.A., San Andrés-Rebollo, F.J., Gómez-Campelo, P., de Burgos-Lunar, C., Cárdenas-Valladolid, J., Abánades-Herranz, J.C., Otero-Puime, A., Jiménez-García, R., López-de-Andrés, A., de Miguel-Yanes, J.M.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Body Mass Index
Cause of Death
Diabetes Mellitus, Type 2 - complications
Diet, Mediterranean
Female
Follow-Up Studies
Gender
Humans
Male
Mediterranean diet
Middle Aged
Mortality
Multivariate Analysis
Obesity - complications
Prospective Studies
Risk Factors
Sex Factors
Spain - epidemiology
Survival Analysis
Type 2 diabetes mellitus
Waist Circumference
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Summary:To analyse the association between body mass index (BMI) and all-cause mortality in a 5-year follow-up study with Spanish type 2 diabetes mellitus (T2DM) patients, seeking gender differences. 3443 T2DM outpatients were studied. At baseline and annually, patients were subjected to anamnesis, a physical examination, and biochemical tests. Data about demographic and clinical characteristics was also recorded, as was the treatment each patient had been prescribed. Mortality records were obtained from the Spanish National Institute of Statistics. Survival curves for BMI categories (Gehan-Wilcoxon test) and a multivariate Cox proportional hazard analysis were performed to identify adjusted Hazard Ratios (HRs) of mortality. Mortality rate was 26.38 cases per 1000patient-years (95% CI, 23.92–29.01), with higher rates in men (28.43 per 1000patient-years; 95% CI, 24.87–32.36) than in women (24.31 per 1000patient-years; 95% CI, 21.02–27.98) (p=0.079). Mortality rates according to BMI categories were: 56.7 (95% CI, 40.8–76.6), 28.4 (95% CI, 22.9–34.9), 24.8 (95% CI, 21.5–28.5), 21 (95% CI, 16.3–26.6) and 23.7 (95% CI, 14.3–37) per 1000person-years for participants with a BMI of 39.4kg/m2, respectively. The BMI values associated with the highest all-cause mortality were
ISSN:0953-6205
1879-0828
DOI:10.1016/j.ejim.2017.06.021