Influence of Epidemiologic and Patient Behavior–Related Predictors on Amputation Rates in Diabetic Patients: Systematic Review and Meta-Analysis

Amputation of patients with diabetic foot is a major issue worldwide, particularly from a medical and economic standpoint. This meta-analysis aimed to identify significant risk factors of high amputation rate among epidemiologic and patient behavior–related predictors in diabetic patients. A systema...

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Bibliographic Details
Published in:International journal of lower extremity wounds 2017-03, Vol.16 (1), p.14-22
Main Authors: Shin, Jin Yong, Roh, Si-Gyun, Lee, Nae-Ho, Yang, Kyung-Moo
Format: Article
Language:English
Subjects:
Amputation - psychology
Amputation - statistics & numerical data
Diabetic Foot - diagnosis
Diabetic Foot - epidemiology
Diabetic Foot - psychology
Diabetic Foot - surgery
Humans
Lower Extremity - surgery
Prognosis
Risk Factors
Smoking - adverse effects
Smoking - epidemiology
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Summary:Amputation of patients with diabetic foot is a major issue worldwide, particularly from a medical and economic standpoint. This meta-analysis aimed to identify significant risk factors of high amputation rate among epidemiologic and patient behavior–related predictors in diabetic patients. A systematic literature review and meta-analysis were performed using MEDLINE, EMBASE, and Cochrane databases. Seven variables were extracted from the included studies and evaluated based on amputation rate. The Newcastle-Ottawa scale was used to assess the quality of the studies. The search strategy identified 101 publications. After screening, 33 articles were selected for review. Male sex and smoking were identified as significant risk factors of high amputation rate of diabetic foot. Although further investigation of long-term and randomized controlled studies is needed, we identified 2 variables as significant risk factors for high amputation rate in diabetic patients in this meta-analysis.
ISSN:1534-7346
1552-6941
DOI:10.1177/1534734617699318