Krebs cycle rewired for macrophage and dendritic cell effector functions

The Krebs cycle is an amphibolic pathway operating in the mitochondrial matrix of all eukaryotic organisms. In response to proinflammatory stimuli, macrophages and dendritic cells undergo profound metabolic remodelling to support the biosynthetic and bioenergetic requirements of the cell. Recently,...

Full description

Saved in:
Bibliographic Details
Published in:FEBS letters 2017-10, Vol.591 (19), p.2992-3006
Main Authors: Ryan, Dylan Gerard, O'Neill, Luke A. J.
Format: Article
Language:English
Subjects:
citrate
Citric Acid Cycle
cytokines
dendritic cell
Dendritic Cells - metabolism
Epigenesis, Genetic
fumarate
Humans
inflammation
Inflammation - metabolism
Inflammation - pathology
itaconate
Krebs cycle
macrophage
Macrophages - metabolism
Models, Biological
succinate
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Krebs cycle is an amphibolic pathway operating in the mitochondrial matrix of all eukaryotic organisms. In response to proinflammatory stimuli, macrophages and dendritic cells undergo profound metabolic remodelling to support the biosynthetic and bioenergetic requirements of the cell. Recently, it has been discovered that this metabolic shift also involves the rewiring of the Krebs cycle to regulate cellular metabolic flux and the accumulation of Krebs cycle intermediates, notably, citrate, succinate and fumarate. Interestingly, a new role for Krebs cycle intermediates as signalling molecules and immunomodulators that dictate the inflammatory response has begun to emerge. This review will discuss the latest developments in Krebs cycle rewiring and immune cell effector functions, with a particular focus on the regulation of cytokine production.
ISSN:0014-5793
1873-3468
DOI:10.1002/1873-3468.12744