Indications and graft survival analysis in optical penetrating keratoplasty in a tertiary care center in North India: a 5-year study

Purpose To study the indications and variables correlating with graft survival in optical penetrating keratoplasty in a tertiary care hospital in north India. Participants All patients who underwent optical keratoplasty, except those undergoing lamellar grafts, tectonic grafts transplants and penetr...

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Bibliographic Details
Published in:International ophthalmology 2018-08, Vol.38 (4), p.1669-1679
Main Authors: Arya, Sudesh Kumar, Raj, Amit, Bamotra, Ravi Kant, Bhatti, Anubha, Deswal, Jyoti, Sindhu, Meenakshi
Format: Article
Language:English
Subjects:
Cornea
Corneal transplantation
Correlation analysis
Females
Graft rejection
Grafting
Grafts
Keratitis
Keratoconus
Males
Medical prognosis
Medicine
Medicine & Public Health
Ophthalmology
Original Paper
Patients
Scars
Surgery
Survival
Survival analysis
Therapeutic applications
Transplants
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Summary:Purpose To study the indications and variables correlating with graft survival in optical penetrating keratoplasty in a tertiary care hospital in north India. Participants All patients who underwent optical keratoplasty, except those undergoing lamellar grafts, tectonic grafts transplants and penetrating keratoplasty done for therapeutic purposes were included in the study. Patients with follow-up less than 2 years were excluded from the study. Materials and methods Data were obtained by reviewing the records of 101 patients who underwent optical penetrating keratoplasty from 2008 to 2013 for various indications. Results Out of 101 patients who underwent optical penetrating keratoplasty, 71 were males and 30 were females. The mean age of the recipient was 48.53 years with range 1–82 years. The main indications were previous failed graft (29.7%), healed keratitis except HSV (15.8%), pseudophakic or aphakic bullous keratopathy (14.8%), corneal dystrophies/degenerations (12.9%), adherent leucoma (9.9%), post-HSV scars (8.9%), and others like anterior staphyloma, congenital corneal opacities, buphthalmos and keratoconus (7.9%). The graft survival rate was 67.33% at 1-year follow-up and 59.4% at 2-year follow-up. The mean survival time of the grafts was 22.42 months. The mean time for graft failure was 7.12 (±0.9) months. Conclusion One- and 2-year survival of grafts at our center is lower as compared to western studies, probably due to higher percentage of poor prognosis indications for surgery and a relative scarcity of excellent-quality donor corneas.
ISSN:0165-5701
1573-2630
DOI:10.1007/s10792-017-0641-0