Morning administration of oral methamphetamine dose-dependently disrupts nighttime sleep in recreational stimulant users

Highlights • Methamphetamine (MA) use is associated with acute sleep disruptions. • We administered 0, 20, and 40 mg MA to recreational stimulant users at 815AM. • MA disrupted sleep continuity and architecture from 10:20PM to 06:15AM. • Effects of MA on sleep were robust and showed clear dose-depen...

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Bibliographic Details
Published in:Drug and alcohol dependence 2017-09, Vol.178, p.291-295
Main Authors: Herrmann, Evan S, Johnson, Patrick S, Vandrey, Ryan, Johnson, Matthew W
Format: Article
Language:English
Subjects:
Acute effects
Adults
Amphetamine-Related Disorders - complications
Amphetamines
Amphetamines - pharmacology
Blindness
Central Nervous System Stimulants - pharmacology
Demographics
Demography
Disruption
Double-Blind Method
Drug abuse
Humans
Insomnia
Latency
Methamphetamine
Methamphetamine - pharmacology
Morning
Night
Nighttime
NREM sleep
Oral administration
Polysomnography
Psychiatry
Quality assessment
Questionnaires
Recreational use
REM
REM sleep
Sleep
Sleep - drug effects
Sleep disorders
Sleep, REM - drug effects
Stimulants
Substance abuse
Substance use
Surveys and Questionnaires
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Summary:Highlights • Methamphetamine (MA) use is associated with acute sleep disruptions. • We administered 0, 20, and 40 mg MA to recreational stimulant users at 815AM. • MA disrupted sleep continuity and architecture from 10:20PM to 06:15AM. • Effects of MA on sleep were robust and showed clear dose-dependence. • Research on MA effects on sleep in naturalistic settings is warranted.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2017.05.013