An esterase-activated click and release approach to metal-free CO-prodrugs

One major challenge in the development of CO as a therapeutic agent is its controllable delivery in a pharmaceutically acceptable form. Herein, we describe for the first time a general chemical strategy to esterase-sensitive organic CO-prodrugs.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (59), p.8296-8299
Main Authors: Ji, Xingyue, Ji, Kaili, Chittavong, Vayou, Yu, Bingchen, Pan, Zhixiang, Wang, Binghe
Format: Article
Language:English
Subjects:
Animals
Carbon Monoxide - chemistry
Carbon Monoxide - metabolism
Carbon Monoxide - pharmacology
Click Chemistry
Dose-Response Relationship, Drug
Esterases - metabolism
Lipopolysaccharides - antagonists & inhibitors
Lipopolysaccharides - pharmacology
Mice
Molecular Structure
Prodrugs - chemistry
Prodrugs - metabolism
Prodrugs - pharmacology
RAW 264.7 Cells
Structure-Activity Relationship
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Tumor Necrosis Factor-alpha - metabolism
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Description
Summary:One major challenge in the development of CO as a therapeutic agent is its controllable delivery in a pharmaceutically acceptable form. Herein, we describe for the first time a general chemical strategy to esterase-sensitive organic CO-prodrugs.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc03832a