Mixed papillary-sarcomatoid carcinoma of the penis: report of an aggressive subtype

Several different histological subtypes of penile carcinoma had been described in the last decades, many with different biological behavior and prognosis. The association of two histological subtypes (mixed tumors) can be observed in one third of the cases. The most common association is of warty an...

Full description

Saved in:
Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2017-12, Vol.471 (6), p.815-818
Main Authors: Bovolim, Graziele, da Costa, Walter Henriques, Guimaraes, Gustavo Cardoso, Soares, Fernando Augusto, da Cunha, Isabela Werneck
Format: Article
Language:English
Subjects:
Brief Report
Cadherins
Carcinoma
Genital cancers
Medicine
Medicine & Public Health
Mesenchyme
Pathology
Penis
Prognosis
Sarcoma
Tumors
Vimentin
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several different histological subtypes of penile carcinoma had been described in the last decades, many with different biological behavior and prognosis. The association of two histological subtypes (mixed tumors) can be observed in one third of the cases. The most common association is of warty and basaloid tumors, two HPV-related carcinomas. Here, we described a mixed papillary-sarcomatoid carcinoma, never reported before. Although it is a clinical aspect of a low-grade verruciform tumor, its prognosis showed it to be very aggressive due to the sarcomatoid component hidden above the papillary component. The two components showed opposite cadherin/vimentin expression pointed to epithelial-mesenchymal transition between them.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-017-2191-2