Clinical evaluations of complete autologous fibrin glue, produced by the CryoSeal® FS System, and polyglycolic acid sheets as wound coverings after oral surgery

The CryoSeal® FS System has been recently introduced as an automated device for the production of complete fibrin glue from autologous plasma, rather than from pool allogenic or cattle blood, to prevent viral infection and allergic reaction. We evaluated the effectiveness of complete autologous fibr...

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Bibliographic Details
Published in:Journal of cranio-maxillo-facial surgery 2017-09, Vol.45 (9), p.1458-1463
Main Authors: Kouketsu, Atsumu, DDS Ph.D, Nogami, Shinnosuke, DDS Ph.D, Yamada-Fujiwara, Minami, MD Ph.D, Nagai, Hirokazu, DDS Ph.D, Yamauchi, Kensuke, DDS Ph.D, Mori, Shiro, DDS Ph.D, Miyashita, Hitoshi, DDS Ph.D, Kawai, Tadashi, DDS Ph.D, Matsui, Aritsune, DDS Ph.D, Kataoka, Yoshihiro, DDS Ph.D, Satomi, Norihisa, DDS Ph.D, Ezoe, Yushi, DDS Ph.D, Abe, Satoko, DDS Ph.D, Takeda, Yuri, DDS Ph.D, Tone, Takeshi, DDS Ph.D, Hirayama, Bunnichi, DDS Ph.D, Kurobane, Tsuyoshi, DDS, Tashiro, Kazuki, DDS, Yanagisawa, Yuta, DDS, Takahashi, Tetsu, DDS Ph.D
Format: Article
Language:English
Subjects:
Autografts
Bandages
Biological Dressings
Dentistry
Fibrin glue
Fibrin Tissue Adhesive
Humans
Mouth - surgery
Mouth Diseases - surgery
Mouth Mucosa - surgery
Mouth Neoplasms - surgery
Oral mucosa
Oral surgery
Oral Surgical Procedures
Polyglycolic Acid
Polyglycolic acid sheet
Precancerous Conditions - surgery
Surgery
Surgical Wound Infection - prevention & control
Tissue Adhesives
Tongue - surgery
Wound Healing
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Summary:The CryoSeal® FS System has been recently introduced as an automated device for the production of complete fibrin glue from autologous plasma, rather than from pool allogenic or cattle blood, to prevent viral infection and allergic reaction. We evaluated the effectiveness of complete autologous fibrin glue and polyglycolic acid (PGA) sheet wound coverings in mucosa defect oral surgery. Postoperative pain, scar contracture, ingestion, tongue dyskinesia, and postoperative bleeding were evaluated in 12 patients who underwent oral (including the tongue) mucosa excision, and received a PGA sheet and an autologous fibrin glue covering. They were compared with 12 patients who received a PGA sheet and commercial allogenic fibrin glue. All cases in the complete autologous fibrin glue group demonstrated good wound healing without complications such as local infection or incomplete cure. All evaluated clinical measures in this group were similar or superior to the commercial allogenic fibrin glue group. Coagulation and adhesion quality achieved with this method was comparable to that with a PGA sheet and commercial fibrin glue. Covering oral surgery wounds with complete autologous fibrin glue produced by an automated device was convenient, safe, and reduced the risk of viral infection and allergic reaction associated with conventional techniques.
ISSN:1010-5182
1878-4119
DOI:10.1016/j.jcms.2017.06.004