Human Semen Quality, Sperm DNA Damage, and the Level of Reproductive Hormones in Relation to Urinary Concentrations of Parabens

OBJECTIVE:The aim of this study was to evaluate the association between environmental exposure to parabens and semen quality parameters [main semen parameters, computer-aided semen analysis (CASA parameters], sperm chromatin structure, and the level of reproductive hormones in men [follicle-stimulat...

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Published in:Journal of occupational and environmental medicine 2017-11, Vol.59 (11), p.1034-1040
Main Authors: Jurewicz, Joanna, Radwan, Michał, Wielgomas, Bartosz, Dziewirska, Emila, Karwacka, Anetta, Klimowska, Anna, Kałużny, Paweł, Radwan, Paweł, Bochenek, Michał, Hanke, Wojciech
Format: Article
Language:English
Subjects:
17β-Estradiol
Adult
Body fluids
Chromatin
Deoxyribonucleic acid
Diagnostic systems
DNA
DNA damage
DNA Fragmentation
Environmental Exposure
Estradiol - blood
Follicle Stimulating Hormone - blood
Follicle-stimulating hormone
Gas chromatography
Hormones
Humans
Infertility
Infertility, Male - blood
Infertility, Male - urine
Male
Mass spectrometry
Mass spectroscopy
Original Article
Parabens - metabolism
Preservatives, Pharmaceutical - metabolism
Saliva
Semen
Semen Analysis
Sex hormones
Sperm
Spermatozoa - pathology
Testosterone
Testosterone - blood
Urinalysis
Urine
Young Adult
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Summary:OBJECTIVE:The aim of this study was to evaluate the association between environmental exposure to parabens and semen quality parameters [main semen parameters, computer-aided semen analysis (CASA parameters], sperm chromatin structure, and the level of reproductive hormones in men [follicle-stimulating hormone (FSH), testosterone, estradiol]. METHODS:Urine samples collected from 315 men who attended the infertility clinic for diagnostic purposes with normal semen concentration of 15 to 300 mln/mL were analyzed for five parabens concentrations using a validated gas chromatography ion-tap mass spectrometry method. Participants were interviewed and also provided a semen, saliva, and blood samples. RESULTS:Urinary parabens concentrations were significantly associated with an increase in the percentage of sperm with abnormal morphology, in sperm with high DNA stainability and a decrease in the percentage of motility and testosterone level. CONCLUSIONS:This is one of the first study on this topic, so the observation of the relationship between parabens and semen quality warrants further investigation.
ISSN:1076-2752
1536-5948
DOI:10.1097/JOM.0000000000001106