Sex-specific association of sex hormones and gonadotropins, with brain amyloid and hippocampal neurodegeneration

Abstract This study aimed to examine the sex-specific association between serum sex hormones and gonadotropins and the cerebral beta-amyloid (Aβ) burden and hippocampal neurodegeneration in subjects with normal cognition (NC) and impaired cognition (IC). Two-hundred and sixty-five older subjects rec...

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Bibliographic Details
Published in:Neurobiology of aging 2017-10, Vol.58, p.34-40
Main Authors: Lee, Jun Ho, Byun, Min Soo, Yi, Dahyun, Choe, Young Min, Choi, Hyo Jung, Baek, Hyewon, Sohn, Bo Kyung, Lee, Jun-Young, Kim, Hyun Jung, Kim, Jee Wook, Lee, Younghwa, Kim, Yu Kyeong, Sohn, Chul-Ho, Woo, Jong Inn, Lee, Dong Young
Format: Article
Language:English
Subjects:
Aged
Alzheimer's disease
Amyloid beta-Peptides - metabolism
Beta-amyloid
Brain - diagnostic imaging
Brain - metabolism
Cognitive Dysfunction - metabolism
Cognitive Dysfunction - pathology
Estradiol - blood
Female
Gonadotropin
Gonadotropins - blood
Hippocampus
Hippocampus - diagnostic imaging
Hippocampus - pathology
Humans
Internal Medicine
Magnetic Resonance Imaging
Male
Nerve Degeneration
Neurodegeneration
Neurology
Organ Size
Positron-Emission Tomography
Sex
Sex Characteristics
Sex hormone
Testosterone - blood
Testosterone - physiology
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Summary:Abstract This study aimed to examine the sex-specific association between serum sex hormones and gonadotropins and the cerebral beta-amyloid (Aβ) burden and hippocampal neurodegeneration in subjects with normal cognition (NC) and impaired cognition (IC). Two-hundred and sixty-five older subjects received clinical assessments, serum measurements of sex hormones, gonadotropins,11 C-Pittsburgh compound B-positron emission tomography, and magnetic resonance imaging. In females, higher free testosterone and gonadotropin levels were associated with lower cerebral Aβ positivity. In males, free testosterone was positively related to hippocampal volume with significant interaction with cognitive status. Further subgroup analyses showed that the association was significant only in IC, but not in NC. Free estradiol was not associated with Aβ burden or hippocampal neurodegeneration in either sex. These results suggest that testosterone might inhibit the early pathological accumulation of Aβ in females and delay neurodegeneration in males.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2017.06.005