Diagnostic value of baseline serum luteinizing hormone level for central precocious puberty in girls

• Published in: Zhongguo dang dai er ke za zhi 2017-07, Vol.19 (7), p.729
• Main Authors: Ou-Yang, Li-Xue, Yang, Fan
• Format: Article
• Language: Chinese
• Subjects: Adolescent; Age Determination by Skeleton; Child; Female; Follicle Stimulating Hormone - blood; Humans; Luteinizing Hormone - blood; Puberty, Precocious - blood; Puberty, Precocious - diagnosis; ROC Curve
• ISSN: 1008-8830
• DOI: 10.7499/j.issn.1008-8830.2017.07.001

To evaluate the diagnostic value of baseline serum luteinizing hormone (LH) level for central precocious puberty (CPP) in girls. A total of 279 girls with precocious puberty were subjected to assessment of growth and development, bone age determination, baseline LH test, and follicle-stimulating hormone (FSH) test, gonadotropin-releasing hormone stimulation test, and other related examinations. Of the 279 patients, 175 were diagnosed with CPP and 104 with premature thelarche (PT). The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of baseline LH and FSH levels and their peak levels for CPP, and the correlation between the baseline LH level and the peak LH level was analyzed. The CPP group had significantly higher bone age, baseline LH and FSH levels, peak LH and FSH levels, and ratio of peak LH level to peak FSH level than the PT group (P11.0 years), baseline LH level showed the best diagnostic value in the >11.0 years subgroup, with the largest area under the ROC curve. At a baseline LH level of 0.45 IU/L, the Youden index reached the peak value, and the sensitivity and specificity were 66.7% and 80% respectively, for the diagnosis of CPP. At a peak LH level of 9.935 IU/L, the Youden index reached the peak value, and the sensitivity and specificity were 74.8% and 100% respectively, for the diagnosis of CPP. The baseline LH level was positively correlated with the peak LH level (r=0.440, P