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Levamisole in frequently-relapsing and steroid-dependent nephrotic syndrome

Objective To evaluate the efficacy of levamisole in children with frequently relapsing nephrotic syndrome (FRNS) and steroid dependent nephrotic syndrome (SDNS) when administered on an alternate day (‘initial therapy’ in all cases) or daily basis (‘rescue therapy’ in whom alternate day therapy faile...

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Bibliographic Details
Published in:Indian pediatrics 2017-10, Vol.54 (10), p.831-834
Main Authors: Samuel, Evangeline Mary Kiruba, Krishnamurthy, Sriram, Bhanudeep, Singanamalla, Muske, Sravani
Format: Article
Language:English
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Summary:Objective To evaluate the efficacy of levamisole in children with frequently relapsing nephrotic syndrome (FRNS) and steroid dependent nephrotic syndrome (SDNS) when administered on an alternate day (‘initial therapy’ in all cases) or daily basis (‘rescue therapy’ in whom alternate day therapy failed). Methods The records of 95 children (age 1–18y) with FRNS (62) and SDNS (33), who were treated at the Pediatric nephrology clinic, and received levamisole therapy (maximum 2 y duration, between 2010–2013) with a follow-up period of minimum 1 y, were included. Results Alternate day levamisole therapy was efficacious in 73.7% ( n =70). The overall efficacy of levamisole therapy was 88.4% ( n =84). Levamisole therapy decreased the mean (SD) number of relapses from 4.22 (0.46)/y to 1.35 (0.36)/y ( P
ISSN:0019-6061
0974-7559
DOI:10.1007/s13312-017-1144-9