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Levamisole in frequently-relapsing and steroid-dependent nephrotic syndrome
Objective To evaluate the efficacy of levamisole in children with frequently relapsing nephrotic syndrome (FRNS) and steroid dependent nephrotic syndrome (SDNS) when administered on an alternate day (‘initial therapy’ in all cases) or daily basis (‘rescue therapy’ in whom alternate day therapy faile...
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Published in: | Indian pediatrics 2017-10, Vol.54 (10), p.831-834 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Objective
To evaluate the efficacy of levamisole in children with frequently relapsing nephrotic syndrome (FRNS) and steroid dependent nephrotic syndrome (SDNS) when administered on an alternate day (‘initial therapy’ in all cases) or daily basis (‘rescue therapy’ in whom alternate day therapy failed).
Methods
The records of 95 children (age 1–18y) with FRNS (62) and SDNS (33), who were treated at the Pediatric nephrology clinic, and received levamisole therapy (maximum 2 y duration, between 2010–2013) with a follow-up period of minimum 1 y, were included.
Results
Alternate day levamisole therapy was efficacious in 73.7% (
n
=70). The overall efficacy of levamisole therapy was 88.4% (
n
=84). Levamisole therapy decreased the mean (SD) number of relapses from 4.22 (0.46)/y to 1.35 (0.36)/y (
P |
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ISSN: | 0019-6061 0974-7559 |
DOI: | 10.1007/s13312-017-1144-9 |