Chronic cold stress modulates the function of peritoneal macrophages in vivo

On day 7 of chronic cold stress, concentration of corticosterone in plasma was established to increase, zymosan-induced production of reactive oxygen species was activated, and IL-10 synthesis by macrophages was enhanced regardless of the opiate receptor blockade. Increase in the concentration of co...

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Bibliographic Details
Published in:Doklady. Biological sciences 2017-05, Vol.474 (1), p.129-131
Main Authors: Gein, S. V., Sharav’eva, I. L.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Cell Biology
Cold Temperature
Corticosterone
Corticosterone - blood
Evolutionary Biology
Interleukin 1
Interleukin 10
Interleukin-10 - metabolism
Interleukin-1beta - metabolism
Life Sciences
Macrophages
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - metabolism
Mice
Naloxone
Naloxone - pharmacology
Opioid receptors
Peritoneum
Plant Sciences
Reactive oxygen species
Reactive Oxygen Species - metabolism
Receptors, Opioid - metabolism
Rodents
Tumor Necrosis Factor-alpha - metabolism
Zymosan - pharmacology
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Summary:On day 7 of chronic cold stress, concentration of corticosterone in plasma was established to increase, zymosan-induced production of reactive oxygen species was activated, and IL-10 synthesis by macrophages was enhanced regardless of the opiate receptor blockade. Increase in the concentration of corticosterone was independent of the blockade of opioid receptors, whereas the zymosan-induced increase in the production of oxygen radicals and activation of the spontaneous production of IL-10 was blocked in mice by naloxone. Chronic cold stress had no effect on the production of IL-1β and TNF-α.
ISSN:0012-4966
1608-3105
DOI:10.1134/S0012496617030127