Dynamics of Torque Teno virus viremia could predict risk of complications after allogeneic hematopoietic stem cell transplantation

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment option for several hematological diseases. However, the first year post-transplantation is often complicated by infections and graft-versus-host disease (GVHD). Improvements in immunological monitoring could r...

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Bibliographic Details
Published in:Medical microbiology and immunology 2017-10, Vol.206 (5), p.355-362
Main Authors: Gilles, Ramona, Herling, Marco, Holtick, Udo, Heger, Eva, Awerkiew, Sabine, Fish, Irina, Höller, Konstantin, Sierra, Saleta, Knops, Elena, Kaiser, Rolf, Scheid, Christof, Di Cristanziano, Veronica
Format: Article
Language:English
Subjects:
Adult
Aged
Biomedical and Life Sciences
Biomedicine
Cell number
Complications
Deoxyribonucleic acid
DNA
Female
Graft vs Host Disease - diagnosis
Graft vs Host Disease - epidemiology
Graft-versus-host reaction
Hematological diseases
Hematology
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Immune response
Immunocompromised hosts
Immunology
Infections
Kinetics
Male
Medical Microbiology
Middle Aged
Original Investigation
Prognosis
Retrospective Studies
Risk Assessment
Risk groups
Stem cell transplantation
Stem cells
Torque teno virus - isolation & purification
Transplantation
Transplantation, Homologous - adverse effects
Transplants & implants
Viral infections
Viral Load
Viremia
Virology
Virus Diseases - diagnosis
Virus Diseases - epidemiology
Viruses
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Description
Summary:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an established treatment option for several hematological diseases. However, the first year post-transplantation is often complicated by infections and graft-versus-host disease (GVHD). Improvements in immunological monitoring could reduce such post-transplant complications. Torque Teno virus (TTV), a chronically persisting DNA virus, is reported to be a marker for immune function in immunocompromised patients. In the present study, the TTV kinetics were analyzed to investigate the potential role of TTV viremia as immune-competence read-out after allo-HSCT. Twenty-three monocentric allo-HSCT recipients were retrospectively tested for TTV-DNA in whole blood at given day post-transplant. Dynamics of TTV viremia was analyzed with respect to episodes of non-TTV viral reactivations (CMV, EBV, and BKPyV), acute GVHD, and recovery of immune cells. Recipients affected by persisting viral infections and/or GVHD during the first 100 days after allo-HSCT showed a significantly higher median TTV load at day +30 than patients with a less complicated clinical course ( p  = 0.005). This was also associated with a total lymphocyte count
ISSN:0300-8584
1432-1831
DOI:10.1007/s00430-017-0511-4